|
Leukemia, Myelocytic, Acute
|
0.320 |
Biomarker
|
disease |
BEFREE |
Collectively, circRNA-DLEU2 accelerated human AML by suppressing miR-496 and promoting PRKACB expression.
|
30037980 |
2018 |
|
Leukemia, Myelocytic, Acute
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
The DLEU2 locus and embedded miRNA cluster miR-15a/16-1 is commonly deleted in adult cancers and shown to induce leukaemogenesis, however in paediatric AML we found the region to be transcriptionally repressed.
|
24885794 |
2014 |
|
Leukemia, Myelocytic, Acute
|
0.320 |
Biomarker
|
disease |
CTD_human |
Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice.
|
21441929 |
2011 |
|
Acute Myeloid Leukemia, M1
|
0.300 |
Biomarker
|
disease |
CTD_human |
Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice.
|
21441929 |
2011 |
|
Acute Myeloid Leukemia (AML-M2)
|
0.300 |
Biomarker
|
disease |
CTD_human |
Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice.
|
21441929 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Herein, the expression of lncRNA DLEU2 was elevated in NSCLC tissues, and its high expression or low expression of miR-30a-5p acted as an independent prognostic factor of poor survival and tumour recurrence in NSCLC.
|
31721438 |
2020 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Glomerular Filtration Rate
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
|
31152163 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
DLEU2 was upregulated in HCC tissues, especially in those larger than 5 cm in tumor size, accompanied with vascular invasion and in worse tumor stage.
|
31376657 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Long noncoding RNA (lncRNA) DLEU2 has been shown to be dysregulated in several type of tumor.
|
30838724 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We also did <i>in vivo</i> experiments to observe tumor formation after overexpression of circRNA-DLEU2.
|
30037980 |
2018 |
|
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
|
30224653 |
2018 |
|
Lipoprotein (a) measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A study of Kibbutzim in Israel reveals risk factors for cardiometabolic traits and subtle population structure.
|
30108283 |
2018 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.
|
28552196 |
2017 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In summary, therapy targeting enhanced host gene Dleu2 transcription may augment CLL therapy.
|
23995789 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Hypermethylation and down-regulation of DLEU2 in paediatric acute myeloid leukaemia independent of embedded tumour suppressor miR-15a/16-1.
|
24885794 |
2014 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The two long non-coding RNA (lncRNA) genes DLEU1 and DLEU2 map to a critical region at chromosomal band 13q14.3 that is recurrently deleted in solid tumors and hematopoietic malignancies like chronic lymphocytic leukemia (CLL).
|
23593011 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We found HDACs inhibitors trichostatin A (TSA) and sodium butyrate upregulated the expression of miR-15a/16-1, residing in the host tumor suppressor Dleu2 gene, through increasing the histone acetylation in the region of Dleu2/miR-15a/16-1 promoter in lung cancer cells.
|
23867991 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Intriguingly, we observed a unique coordination in the splicing of MDM2-ALT1 and MDM4-ALT2 in approximately 24% of tumor samples in a manner similar to genotoxic stress response in cell lines.
|
24027430 |
2013 |
|
Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia.
|
20060366 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way.
|
19591824 |
2009 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that RFP2, c13ORF1, and a chromosome 13-specific ST13-like gene, FAM10A4, are the most likely candidates for such a type of B-CLL TSG.
|
14499696 |
2003 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
RB1, CLLD7, KPNA3, CLLD6, and RFP2 were down-regulated in B-CLL patients as compared with B cells of healthy donors, with RFP2 showing the most pronounced loss of expression.
|
12010815 |
2002 |