CCK, cholecystokinin, 885

N. diseases: 326; N. variants: 7
Disease: Catalepsy ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007370
Disease: Catalepsy
Catalepsy 		0.300 Therapeutic disease CTD_human For the inhibition of catalepsy CCK-8-NS was the more active as it decreased catalepsy scores even 120 min after administration. 2862602 1985
CUI: C0007370
Disease: Catalepsy
Catalepsy 		0.300 Therapeutic disease CTD_human Furthermore, the catalepsy induced by CCK-8-SE was of short duration.With icv. administration only 40 pmole CCK-8-NS induced significant catalepsy.When 0.2, 0.4 and 0.8 mumole/kg sc. doses of CCK-8-NS or 0.4 pmole icv. dose of CCK-8-SE or CCK-8-NS was given in combination with intraperitoneal (ip.) administration of 1.0 mg/kg haloperidol, the total duration of catalepsy was suppressed.Finally, CCK-8-SE sc. when given in combination with haloperidol ip., exerted a biphasic, synergistic-antagonistic effect on the haloperidol-induced catalepsy. 4040614 1985