Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.420 Biomarker disease BEFREE The second-most significant site (P = 1.38 × 10-9, q = 0.013) was located in ALDH1A2, which encodes an enzyme for astrocyte-derived retinoic acid-a key neuronal morphogen with relevance for schizophrenia. 31165892 2020
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.420 GeneticVariation disease BEFREE Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant. 29732726 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.420 GeneticVariation disease BEFREE These findings indicate that the SNP rs4238326 in ALDH1A2 gene may potentially modify individual susceptibility to knee OA in the Chinese population. 28089900 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.420 GeneticVariation disease GWASCAT Genome-wide association study of schizophrenia in Ashkenazi Jews. 26198764 2015
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.420 GeneticVariation disease GWASCAT Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31. 24728293 2014
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.420 Biomarker disease CTD_human Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31. 24728293 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.420 Biomarker disease BEFREE In the present study we chose to investigate 7 genes involved in the synthesis, degradation and transportation of RA, ALDH1A1, ALDH1A2, ALDH1A3, CYP26A1, CYP26B1, CYP26C1 and Transthyretin (TTR), for their roles in the development of schizophrenia. 19703508 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.420 Biomarker disease PSYGENET In the present study we chose to investigate 7 genes involved in the synthesis, degradation and transportation of RA, ALDH1A1, ALDH1A2, ALDH1A3, CYP26A1, CYP26B1, CYP26C1 and Transthyretin (TTR), for their roles in the development of schizophrenia. 19703508 2009
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.320 GeneticVariation disease BEFREE SNPs within ALDH1A2 associated with prostate cancer mortality were rs1441817 (fixed effects hazard ratio, HR<sub>fixed</sub>  = 0.78; 95% confidence interval (95%CI):0.66,0.91; p values = 0.002); rs12910509, HR<sub>fixed</sub>  = 0.76; 95%CI:0.64,0.91; p values = 0.003); and rs8041922 (HR<sub>fixed</sub>  = 0.76; 95%CI:0.64,0.91; p values = 0.002). 27643404 2017
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.320 Biomarker disease BEFREE Taken together, our findings implicate ALDH1a2 as a candidate tumor suppressor gene in prostate cancer and further support a role of retinoids in the prevention or treatment of prostate cancer. 16166285 2005
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.320 Biomarker disease CTD_human Taken together, our findings implicate ALDH1a2 as a candidate tumor suppressor gene in prostate cancer and further support a role of retinoids in the prevention or treatment of prostate cancer. 16166285 2005
CUI: C0025312
Disease: Meningomyelocele
Meningomyelocele 		0.310 GeneticVariation disease BEFREE These results may suggest that polymorphisms in ALDH1A2 may influence the risk for lumbosacral myelomeningocele in humans. 16237707 2005
CUI: C0025312
Disease: Meningomyelocele
Meningomyelocele 		0.310 GeneticVariation disease LHGDN These results may suggest that polymorphisms in ALDH1A2 may influence the risk for lumbosacral myelomeningocele in humans. 16237707 2005
CUI: C0025312
Disease: Meningomyelocele
Meningomyelocele 		0.310 Biomarker disease CTD_human These results may suggest that polymorphisms in ALDH1A2 may influence the risk for lumbosacral myelomeningocele in humans. 16237707 2005
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.310 GeneticVariation group BEFREE Using bisulfite sequencing, we determined that the ALDH1a2 promoter region was significantly hypermethylated in primary prostate tumors compared with normal prostate specimens (P = 0.01). 16166285 2005
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.310 Biomarker group CTD_human Using bisulfite sequencing, we determined that the ALDH1a2 promoter region was significantly hypermethylated in primary prostate tumors compared with normal prostate specimens (P = 0.01). 16166285 2005
CUI: C0086743
Disease: Osteoarthrosis Deformans
Osteoarthrosis Deformans 		0.300 Biomarker disease CTD_human Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31. 24728293 2014
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders 		0.300 Biomarker group CTD_human Benomyl, aldehyde dehydrogenase, DOPAL, and the catecholaldehyde hypothesis for the pathogenesis of Parkinson's disease. 25045800 2014
CUI: C0242423
Disease: Ramsay Hunt Paralysis Syndrome
Ramsay Hunt Paralysis Syndrome 		0.300 Biomarker disease CTD_human Benomyl, aldehyde dehydrogenase, DOPAL, and the catecholaldehyde hypothesis for the pathogenesis of Parkinson's disease. 25045800 2014
CUI: C0752097
Disease: Autosomal Dominant Juvenile Parkinson Disease
Autosomal Dominant Juvenile Parkinson Disease 		0.300 Biomarker disease CTD_human Benomyl, aldehyde dehydrogenase, DOPAL, and the catecholaldehyde hypothesis for the pathogenesis of Parkinson's disease. 25045800 2014
CUI: C0752098
Disease: Autosomal Dominant Parkinsonism
Autosomal Dominant Parkinsonism 		0.300 Biomarker disease CTD_human Benomyl, aldehyde dehydrogenase, DOPAL, and the catecholaldehyde hypothesis for the pathogenesis of Parkinson's disease. 25045800 2014
CUI: C0752100
Disease: Autosomal Recessive Parkinsonism
Autosomal Recessive Parkinsonism 		0.300 Biomarker disease CTD_human Benomyl, aldehyde dehydrogenase, DOPAL, and the catecholaldehyde hypothesis for the pathogenesis of Parkinson's disease. 25045800 2014
CUI: C0752101
Disease: Parkinsonism, Experimental
Parkinsonism, Experimental 		0.300 Biomarker disease CTD_human Benomyl, aldehyde dehydrogenase, DOPAL, and the catecholaldehyde hypothesis for the pathogenesis of Parkinson's disease. 25045800 2014
CUI: C0752104
Disease: Familial Juvenile Parkinsonism
Familial Juvenile Parkinsonism 		0.300 Biomarker disease CTD_human Benomyl, aldehyde dehydrogenase, DOPAL, and the catecholaldehyde hypothesis for the pathogenesis of Parkinson's disease. 25045800 2014
CUI: C0752105
Disease: Parkinsonism, Juvenile
Parkinsonism, Juvenile 		0.300 Biomarker disease CTD_human Benomyl, aldehyde dehydrogenase, DOPAL, and the catecholaldehyde hypothesis for the pathogenesis of Parkinson's disease. 25045800 2014