|
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, β-carotene significantly suppressed protein expression of TNF-α, IL-1β, and MCP-1 and mRNA expression of TSLP, IL-6, IL-1β, IL-4, IL-5, and Par-2 in AD-like skin tissues.
|
31292344 |
2019 |
|
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Itch, inflammation, and atopic dermatitis are associated with activation of PAR2.
|
30471839 |
2019 |
|
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
House dust mite-treated PAR2 over-expressor mouse: A novel model of atopic dermatitis.
|
31487753 |
2019 |
|
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we tested the ability of a cell-penetrating pepducin, PZ-235, to mitigate the potentially deleterious effects of PAR2 in models of atopic dermatitis.
|
30287285 |
2019 |
|
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, PXR activation by environmental pollutants may compromise epidermal barrier function and favor an immune response resembling atopic dermatitis.
|
28927887 |
2018 |
|
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epidemiological evidence suggests that environmental pollutants contribute to atopic dermatitis, but mechanistic details are currently lacking.Elentner et al. show that PXR, a key transcription factor involved in pollutant metabolism, drives features of subclinical atopic dermatitis.
|
29273149 |
2018 |
|
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings may provide clues to understanding the pathological role of DhPKs in skin disorders in which PAR2 is known to be involved, such as atopic dermatitis, Netherton syndrome, and psoriasis.
|
29458120 |
2018 |
|
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Persistent kallikrein 5 activation induces atopic dermatitis-like skin architecture independent of PAR2 activity.
|
28238749 |
2017 |
|
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Drugs targeting the nonhistaminergic (PAR2/TRPA1) itch pathway and itch sensitization are promising for treating AD itch.
|
28614190 |
2017 |
|
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A number of genes, including CC chemokine receptor 4, T cell-specific tyrosine kinase (Emt/Itk), integrin beta1, integrin alpha6, IQGAP1 and MAR/SAR DNA-binding protein (SATB1), were shown to be more highly expressed in patients with moderate and/or severe AD than in controls or patients with mild AD.
|
12483038 |
2002 |