Disease: Tuberculosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.090 GeneticVariation disease BEFREE Genetic polymorphisms in PXR and NF-κB1 influence susceptibility to anti-tuberculosis drug-induced liver injury. 31490979 2019
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.090 AlteredExpression disease BEFREE SAR and cheminformatics studies of commercially available analogues point to a series of benzimidazolium derivatives, here named N2, with bactericidal activity on different mycobacteria, including M. abscessus, multidrug-resistant M. tuberculosis, and dormant M. smegmatis. 30969758 2019
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.090 Biomarker disease BEFREE Thrombin Upregulates PAI-1 and Mesothelial-Mesenchymal Transition Through PAR-1 and Contributes to Tuberculous Pleural Fibrosis. 31614900 2019
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.090 Biomarker disease BEFREE The potency enhancing properties of the spiro-fused ring motif was affirmed by SAR and validated in a mouse model of tuberculosis. 29894180 2018
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.090 Biomarker disease BEFREE We conclude that PXR activation in macrophages compromises the efficacy of the anti-TB drug rifampicin. 29358328 2018
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.090 Biomarker disease BEFREE New insights into the SAR and drug combination synergy of 2-(quinolin-4-yloxy)acetamides against Mycobacterium tuberculosis. 27914363 2017
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.090 Biomarker disease BEFREE Further studies are needed to determine the overall impact of PXR activation on the outcome of TB therapy. 26592418 2016
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.090 Biomarker disease BEFREE In this study, we demonstrate that PXR augments M. tuberculosis survival inside the host macrophages by promoting the foamy macrophage formation and abrogating phagolysosomal fusion, inflammation, and apoptosis. 27233963 2016
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.090 GeneticVariation disease BEFREE The result suggests that in Indonesian patients with tuberculosis, the risk of having AT-DILI was associated with TT genotype of the PXR gene. 26417664 2015