Acute Coronary Syndrome
|
0.010 |
Biomarker
|
disease |
LHGDN |
[Protein Z: a new regulator of coagulation in arterial vessels?].
|
15314579 |
2004 |
Anemia, Sickle Cell
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
As Protein Z and Endothelin-1 genetic polymorphisms may increase the thrombotic risk, the aim of the current work was to verify the possible impact of Protein Z (PROZ G79A) and Endothelin-1 (EDN1 G5665T) polymorphisms on the clinic-laboratory features of the SCD in a cohort of Egyptian pediatric patients.
|
28548215 |
2018 |
Behcet Syndrome
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Decreased protein Z concentrations complicating the hypercoagulable state of Behçet's disease.
|
14507116 |
2003 |
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Brain Ischemia
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young.
|
14671240 |
2004 |
Cerebral Infarction
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Circulating protein Z concentration, PROZ variants, and unexplained cerebral infarction in young and middle-aged adults.
|
27683756 |
2017 |
Cerebral Infarction
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We investigated a possible association of 2 common single nucleotide mutations in the PZ gene with the risk of cerebral ischemia.
|
14671240 |
2004 |
Cerebral Infarction
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We identified the functional variant rs494860 in the protein Z (PROZ) gene as our strongest association with occurrence of cerebral infarction (odds ratio (OR) 0.49 (95% confidence interval 0.33-0.73), p = 5.2 × 10<sup>-4</sup>).
|
29746949 |
2018 |
Cerebrovascular accident
|
0.040 |
AlteredExpression
|
group |
LHGDN |
A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young.
|
14671240 |
2004 |
Cerebrovascular accident
|
0.040 |
GeneticVariation
|
group |
BEFREE |
We investigated PZ levels and PROZ variants in a multi-ethnic case-control study of unexplained stroke in participants aged 18 to 64.
|
27683756 |
2017 |
Cerebrovascular accident
|
0.040 |
AlteredExpression
|
group |
LHGDN |
Protein Z in ischemic stroke and its etiologic subtypes.
|
12970515 |
2003 |
Cerebrovascular accident
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Furthermore, a protective role in juvenile stroke was shown for a SNP of the vitamin K dependent protein Z (PZ Intron F G79A) which is linked with low PZ levels.
|
16155788 |
2006 |
Kidney Diseases
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Protein Z is reduced in chronic kidney disease and not elevated in patients on haemodialysis.
|
18180611 |
2008 |
Multiple Chronic Conditions
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated PZ levels and PROZ variants in a multi-ethnic case-control study of unexplained stroke in participants aged 18 to 64.
|
27683756 |
2017 |
Pre-Eclampsia
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
Preeclampsia is associated with low concentrations of protein Z.
|
17701666 |
2007 |
PROTEIN Z DEFICIENCY
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
PROTEIN Z DEFICIENCY
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
R255h amino acid substitution of protein Z identified in patients with factor V Leiden mutation.
|
15638861 |
2005 |
Pyelonephritis
|
0.010 |
Biomarker
|
disease |
LHGDN |
Pyelonephritis during pregnancy: a cause for an acquired deficiency of protein Z.
|
18828054 |
2008 |
Skin Pigmentation
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Identification of a novel locus associated with skin colour in African-admixed populations.
|
28300201 |
2017 |
Venous Thrombosis
|
0.010 |
GeneticVariation
|
phenotype |
LHGDN |
The G79A polymorphism of protein Z gene is an independent risk factor for cerebral venous thrombosis.
|
18677630 |
2008 |