|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
These results demonstrated that in PVN apelin induced long-term high blood pressure and sympathetic activity via increasing oxidative stress.
|
31657686 |
2019 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
The enhanced activity of endogenous apelin and APJ receptor in PVN contributes to sympathetic activation in hypertension, and the superoxide anion is involved in these apelin-mediated processes in PVN.
|
30582943 |
2019 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Recent studies have investigated the association of apelin polymorphisms and hypertension risk, but no meta-analysis has been conducted.
|
30755060 |
2019 |
|
Hypertensive disease
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Recent evidence supports that low apelin and relaxin plasma levels contribute to vascular damage accelerating atherogenesis and predisposing to HTN and cardiovascular (CV) events.
|
30525273 |
2019 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
By antagonizing the RAA system, apelin could play an important role in heart failure and hypertension.
|
30659278 |
2019 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
These results were more evident when the group of patients without hypertension were divided based in normal and high-normal BP, observing that apelin-17 isoform were higher in individuals with high-normal BP in comparison to subjects with normal BP (P = 0.018); concentrations were also higher when compared to subjects with hypertension (P = 0.004).
|
29652188 |
2018 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
All participants including 645 hypertensive patients and 362 normotensive controls were genotyped for 4 gene polymorphisms associated with hypertension susceptibility including Apelin (rs909656, rs5975126) and APJ (rs10501367, rs11544374).
|
29800734 |
2018 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
However, the role of APJ interaction with opioid receptors (OPR) on the cardiovascular effects of apelin in hypertension is not clear.
|
28945940 |
2018 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
This study analyzed the interaction between APJ and kappa OPRs (KOR) in cardiac responsiveness to apelin in acute reno-vascular hypertension (2K1C).
|
30627376 |
2018 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
These results show that endogenous apelin, acting via APJ, is not involved in the genesis or maintenance of hypertension in either animal model used in this study.
|
30459635 |
2018 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
We think that our findings may contribute to experimental or clinical studies related to hypertension and apelin.
|
29395316 |
2018 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
ELA through the apelin (APJ) receptor promotes angiogenesis in vitro, relaxes murine aortic blood vessels and attenuates high blood pressure in vivo.
|
27903222 |
2017 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Lowered circulating apelin is significantly associated with an increased risk for hypertension: A meta-analysis.
|
28534648 |
2017 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
Our data confirm a role for the apelin peptide system in cardiovascular regulation at the level of the RVLM and highlight that this system is a possible potential therapeutic target for the treatment of hypertension.
|
28255983 |
2017 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
Treatment-associated change in apelin concentration in patients with hypertension and its relationship with left ventricular diastolic function.
|
27599667 |
2017 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
Apelin- induced recovery of ERK1/2 phosphorylation and KOR-APJ dimerization may nominate apelin as a therapeutic goal in treatment of this kind of hypertension.
|
28987634 |
2017 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
The aim of this study was to evaluate if polymorphisms of APLN and APLNR genes may play a role as susceptibility markers for hypertension in a group of Mexican-Mestizo patients.
|
27450650 |
2016 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
In conclusion, gene polymorphisms of the apelin-APJ system are associated with susceptibility to hypertension.
|
27338090 |
2016 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
The aim of this study was to interrogate the gender-specific association of 5 well-defined polymorphisms in apelin/APJ system with both blood pressure changes and hypertension risk in a northeastern Chinese population.
|
27863393 |
2016 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Our findings demonstrate that genetic defects in AGTR2 and apelin genes by themselves may play an independent leading role in determining susceptibility to hypertension in both genders.
|
25143330 |
2015 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
In this Chinese population, Apelin and APLN SNP rs3761581 was associated with combined hypertension with CRAE, indicating that the expression of APLN gene products may be involved in vascular injury.
|
25272042 |
2015 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
However, the role of apelin on these pathogenic conditions was not consistent, consequently, the contradictory role of apelin on these pathogenesis of hypertension would be discussed in this article.
|
24990699 |
2014 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Although the functional role of the G212A polymorphism has not yet been identified, it is possible to hypothesize that the presence of the A allele may cause a gain in function of the apelin/APJ system associated with a lower risk of hypertension.
|
22109355 |
2012 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Via sequencing the genes of apelin/angiotensin receptor-like 1 (apelin/APJ) pathway, we have recently identified and validated four common polymorphisms (rs3761581, rs56204867, rs7119375, and rs10501367) implicated in the development of hypertension.
|
23226564 |
2012 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension.
|
21233449 |
2011 |