|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Apelin, an adipokine associated with obesity, and its receptor, APJ, participate in lymphatic invasion.
|
31264472 |
2020 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Apelin-36-[L28A] and Apelin-36-[L28C(30kDa-PEG)] peptides that improve diet induced obesity are G protein biased ligands at the apelin receptor.
|
31472173 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
However, there is still a lack of evidence on the association of apelin concentration with different exercise types in middle-aged obese women This study aimed to investigate the effects of 8 weeks of aerobic and resistance exercises on apelin-12 and apelin-36 levels and thereby verify the effects of different exercise types in obese, middle-aged women.
|
30696454 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
We found no evidence that apelin constitutes an endocrine link between maternal obesity and fetal overgrowth.
|
30835509 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Apelin, a peptide hormone that has been linked to insulin resistance, obesity and glucose metabolism, coexists with arginine vasopressin (AVP) in hypothalamic magnocellular neurons that control body fluid homeostasis.
|
30334404 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Thus, stable analogues of apelin-13 have potential for diabetes/obesity therapy.
|
29412822 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Upregulated expression of resistin, vaspin, apelin and TNF-α plays a significant role in induction of insulin resistance linked with obesity and type 2 diabetes.
|
29229313 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
On the other hand, many animal models and clinical studies have demonstrated that apelin, an adipocytokine, is related to the obesity and T2DM.
|
29101069 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
To our knowledge, this is the first study regarding the differences of apelin-17 isoform concentrations in individuals pertaining to different categories of BP, who presented obesity class 3.
|
29652188 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Overproduction of apelin in obesity could be one of the last protective defenses before type 2 diabetes develops.
|
28125271 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The findings of the study suggest that apelin-13 may not only lead to obesity by increasing body weight but also cause infertility by suppressing reproductive hormones.
|
27494693 |
2017 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Serum omentin-1, vaspin, and apelin levels and central obesity in patients with nonalcoholic fatty liver disease.
|
28616057 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
These results indicate that apelin inhibits HFD-induced obesity by enhancing vessel integrity.
|
23378608 |
2013 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Recently, apelin, synthesised and secreted by adipocytes, has been described as a beneficial adipokine related to obesity, and there is growing awareness of a potential role for apelin and APJ in glucose and energy metabolism.
|
23943882 |
2013 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Obesity surgery-induced weight loss causes a significant reduction in omental and SC apelin expression.
|
23429279 |
2013 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
A positive correlation between plasma apelin concentrations and obesity traits was reported.
|
21775567 |
2011 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Apelin is a prerequisite factor for anti-obesity by stimulating energy expenditure via regulating homeostatic energy balance.
|
21609753 |
2011 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Thus we studied apelin and APJ expression in AT and muscle in different mice models of obesity and in type 2 diabetic patients.
|
20233941 |
2010 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
RGD |
It has been reported that apelin functions as an adipokine, which has been associated to obesity and insulin resistance.
|
17594060 |
2007 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Apelin synthesis in adipocytes is stimulated by insulin, and plasma apelin level markedly increases in obesity associated with insulin resistance and hyperinsulinemia.
|
16733497 |
2006 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In different mouse models of obesity, expression of both TNFalpha and apelin was also significantly increased in adipocytes of obese mice.
|
16723381 |
2006 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
A comparison of four different models of obesity in mice showed a large increase in both apelin expression in fat cells and apelin plasma levels in all the hyperinsulinemia-associated obesities and clearly demonstrated that obesity or high-fat feeding are not the main determinants of the rise of apelin expression.
|
15677759 |
2005 |