|
Liver carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Ectopic APLN expression in HCC cells promoted cell proliferation, accelerated G1/S progression and inhibited apoptosis, whilst APLN knockdown exerted opposite effects <i>in vitro</i> and inhibited HCC xenograft growth in mice.
|
31410213 |
2019 |
|
Liver carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Hepatoprotective activities of Fc-apelin against inflammation were evaluated in LPS mice and/or hepatoma Huh-7 cells with respect to serum ALT, apoptosis, oxidative stress, macrophage infiltration and gene expression.
|
30061611 |
2018 |
|
Liver carcinoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
|
Liver carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
HCC with irregular dilated arteries expressed higher levels of apelin (p=0.012).
|
25275024 |
2014 |
|
Hyperuricemia
|
0.310 |
Therapeutic
|
disease |
CTD_human |
However, 2-week apelin-13 treatment had no obvious effect on the rats with hyperuricemia.
|
30710622 |
2019 |
|
Hyperuricemia
|
0.310 |
Biomarker
|
disease |
BEFREE |
However, 2-week apelin-13 treatment had no obvious effect on the rats with hyperuricemia.
|
30710622 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Apelin, an adipokine associated with obesity, and its receptor, APJ, participate in lymphatic invasion.
|
31264472 |
2020 |
|
Heart failure
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The apelin receptor is a potential target in the treatment of heart failure and pulmonary arterial hypertension where levels of endogenous apelin peptides are reduced but significant receptor levels remain.
|
30901161 |
2019 |
|
Heart failure
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In this study, we determined how post-infarct heart failure (HF) and a high fat diet (HFD) affect expression of the apelin APJ receptor (APJR) and the V1a (V1aR) and V1b (V1bR) vasopressin receptors in the hypothalamus, the heart, and the retroperitoneal adipose tissue.
|
31645268 |
2019 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Activation of the apelin receptor, or APJ, by apelin is considered a therapeutic avenue for cardiovascular disease, including heart failure.
|
31101543 |
2019 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
By antagonizing the RAA system, apelin could play an important role in heart failure and hypertension.
|
30659278 |
2019 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
The APJ receptor and its endogenous peptidic ligand apelin have been implicated as important modulators of cardiovascular function, and APJ receptor agonists may be beneficial in the treatment of heart failure.
|
31724863 |
2019 |
|
Heart failure
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The ischemic HF rats were treated with apelin or saline for 12 weeks.
|
31316680 |
2019 |
|
Congestive heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
The APJ receptor and its endogenous peptidic ligand apelin have been implicated as important modulators of cardiovascular function, and APJ receptor agonists may be beneficial in the treatment of heart failure.
|
31724863 |
2019 |
|
Congestive heart failure
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The ischemic HF rats were treated with apelin or saline for 12 weeks.
|
31316680 |
2019 |
|
Congestive heart failure
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The apelin receptor is a potential target in the treatment of heart failure and pulmonary arterial hypertension where levels of endogenous apelin peptides are reduced but significant receptor levels remain.
|
30901161 |
2019 |
|
Congestive heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Activation of the apelin receptor, or APJ, by apelin is considered a therapeutic avenue for cardiovascular disease, including heart failure.
|
31101543 |
2019 |
|
Congestive heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
By antagonizing the RAA system, apelin could play an important role in heart failure and hypertension.
|
30659278 |
2019 |
|
Congestive heart failure
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In this study, we determined how post-infarct heart failure (HF) and a high fat diet (HFD) affect expression of the apelin APJ receptor (APJR) and the V1a (V1aR) and V1b (V1bR) vasopressin receptors in the hypothalamus, the heart, and the retroperitoneal adipose tissue.
|
31645268 |
2019 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
These results demonstrated that in PVN apelin induced long-term high blood pressure and sympathetic activity via increasing oxidative stress.
|
31657686 |
2019 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
The enhanced activity of endogenous apelin and APJ receptor in PVN contributes to sympathetic activation in hypertension, and the superoxide anion is involved in these apelin-mediated processes in PVN.
|
30582943 |
2019 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Recent studies have investigated the association of apelin polymorphisms and hypertension risk, but no meta-analysis has been conducted.
|
30755060 |
2019 |
|
Hypertensive disease
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Recent evidence supports that low apelin and relaxin plasma levels contribute to vascular damage accelerating atherogenesis and predisposing to HTN and cardiovascular (CV) events.
|
30525273 |
2019 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
By antagonizing the RAA system, apelin could play an important role in heart failure and hypertension.
|
30659278 |
2019 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Apelin-36-[L28A] and Apelin-36-[L28C(30kDa-PEG)] peptides that improve diet induced obesity are G protein biased ligands at the apelin receptor.
|
31472173 |
2019 |