|
Neoplasms
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Study distribution by tumor was as follows: breast cancer (n=15), prostate cancer (n=3), pancreatic cancer (n=2), non-Hodgkin's lymphoma (n=2), glioma (n=1), chronic lymphocytic leukemia (n=1), colorectal cancer (n=1), non-small cell lung cancer (n=1) and ovarian cancer (n=1).We identified 10 single nucleotide polymorphisms (SNPs) significantly associated with cancer risk: NPAS2 rs10165970 (mixed and breast cancer shiftworkers), rs895520 (mixed), rs17024869 (breast) and rs7581886 (breast); CLOCK rs3749474 (breast) and rs11943456 (breast); RORA rs7164773 (breast and breast cancer postmenopausal), rs10519097 (breast); RORB rs7867494 (breast cancer postmenopausal), PER3 rs1012477 (breast cancer subgroups) and assessed the level of quality evidence to be intermediate.
|
28177907 |
2017 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
PER3 is related to tumor differentiation and the progression of colorectal cancer.
|
24393525 |
2014 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Pairwise correlations between functionally-related clock genes (e.g., PER2-PER3 and CRY2-PER3) were stronger in ER+, HER2- and low-grade carcinomas; whereas, weaker correlation coefficients were observed in ER- and HER2+ tumors, high-grade tumors and tumors that progressed to metastatic disease.
|
25485508 |
2014 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
In addition, PER3 expression was related to multiple clinicopathologic factors, including tumor location, differentiation, and stage.
|
22350604 |
2012 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Downregulated PER3 and upregulated TIM expression correlated with larger tumor size (p < 0.05), and lower expression of PER3 correlated with deeper tumor invasion (p < 0.05).
|
22081375 |
2012 |
|
Neoplasms
|
0.080 |
GeneticVariation
|
group |
BEFREE |
We identified three genes matching all of our selection criteria for a tumor-suppressor gene (period homolog 3 [PER3], insulin-like growth-factor-binding protein, acid labile subunit [IGFALS], and protein Z).
|
22689435 |
2012 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
In the tumor tissue of CRC patients, compared to their matched healthy mucosa, expression levels of ARNTL1 (p=.002), PER1 (p=.002), PER2 (p=.011), PER3 (p=.003), and CRY2 (p=.012) were lower, whereas the expression level of TIM (p=.044) was higher.
|
22080729 |
2011 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Disruption of PER3 function may serve as an indicator of probability of tumor recurrence in patients with ER-positive tumors.
|
20625127 |
2010 |