|
Advanced Sleep-Phase Syndrome, Familial
|
0.500 |
GermlineCausalMutation
|
disease |
ORPHANET |
A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait.
|
26903630 |
2016 |
|
Advanced Sleep-Phase Syndrome, Familial
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Depressive disorder
|
0.430 |
GeneticVariation
|
disease |
BEFREE |
The PER3 length polymorphism (rs57875989) was significantly associated with depression in this sample, and individuals homozygous for the PER3 single nucleotide polymorphism (SNP) (rs228697) reported significantly higher anxiety.
|
29614896 |
2018 |
|
Depressive disorder
|
0.430 |
GeneticVariation
|
disease |
BEFREE |
We conclude that genetic polymorphisms in circadian genes (especially hClock and hPer3, where functional assays could be tested) influence risk of developing depression in a sex- and stress-dependent manner.
|
26926884 |
2016 |
|
Depressive disorder
|
0.430 |
Biomarker
|
disease |
PSYGENET |
Polymorphisms in the CLOCK, BMAL1, Per3 and TIMELESS genes have been associated with susceptibility to mood disorder, and single nucleotide polymorphisms and haplotypes in several circadian genes have been observed among those displaying certain circadian phenotypes, including worse mood in the evening, insomnia in mania and early, middle or late insomnia in depression.
|
19708722 |
2009 |
|
Depressive disorder
|
0.430 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the CLOCK, BMAL1, Per3 and TIMELESS genes have been associated with susceptibility to mood disorder, and single nucleotide polymorphisms and haplotypes in several circadian genes have been observed among those displaying certain circadian phenotypes, including worse mood in the evening, insomnia in mania and early, middle or late insomnia in depression.
|
19708722 |
2009 |
|
Depressive disorder
|
0.430 |
Biomarker
|
disease |
PSYGENET |
Adjusted mean serum cytokine concentrations (IL-6, TNF-alpha, gamma-INF, IL-1ra, IL-1-beta, VEGF) were compared among patients with high and low scores for fatigue (Multidimensional Fatigue Inventory), depressive symptoms (Beck Depression Inventory II), or sleep disruption (Pittsburgh Sleep Quality Index), or among patients with different Per3 clock gene variants.
|
19926609 |
2009 |
|
Depressive disorder
|
0.430 |
Biomarker
|
disease |
HPO |
|
|
|
|
Malignant neoplasm of breast
|
0.370 |
Biomarker
|
disease |
BEFREE |
Out of 17 genes investigated, 15 were found to be significantly associated with the risk of cancer: four genes were shared by all three malignancies (ARNTL, CLOCK, RORA and RORB), two by breast and lung cancer (CRY1 and CRY2) and three by prostate and lung cancer (NPAS2, NR1D1 and PER3), whereas four genes were specific for lung cancer (ARNTL2, CSNK1E, NR1D2 and PER2) and two for breast cancer (PER1, RORC).
|
29455641 |
2018 |
|
Breast Carcinoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
Out of 17 genes investigated, 15 were found to be significantly associated with the risk of cancer: four genes were shared by all three malignancies (ARNTL, CLOCK, RORA and RORB), two by breast and lung cancer (CRY1 and CRY2) and three by prostate and lung cancer (NPAS2, NR1D1 and PER3), whereas four genes were specific for lung cancer (ARNTL2, CSNK1E, NR1D2 and PER2) and two for breast cancer (PER1, RORC).
|
29455641 |
2018 |
|
Malignant neoplasm of breast
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Study distribution by tumor was as follows: breast cancer (n=15), prostate cancer (n=3), pancreatic cancer (n=2), non-Hodgkin's lymphoma (n=2), glioma (n=1), chronic lymphocytic leukemia (n=1), colorectal cancer (n=1), non-small cell lung cancer (n=1) and ovarian cancer (n=1).We identified 10 single nucleotide polymorphisms (SNPs) significantly associated with cancer risk: NPAS2 rs10165970 (mixed and breast cancer shiftworkers), rs895520 (mixed), rs17024869 (breast) and rs7581886 (breast); CLOCK rs3749474 (breast) and rs11943456 (breast); RORA rs7164773 (breast and breast cancer postmenopausal), rs10519097 (breast); RORB rs7867494 (breast cancer postmenopausal), PER3 rs1012477 (breast cancer subgroups) and assessed the level of quality evidence to be intermediate.
|
28177907 |
2017 |
|
Breast Carcinoma
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Study distribution by tumor was as follows: breast cancer (n=15), prostate cancer (n=3), pancreatic cancer (n=2), non-Hodgkin's lymphoma (n=2), glioma (n=1), chronic lymphocytic leukemia (n=1), colorectal cancer (n=1), non-small cell lung cancer (n=1) and ovarian cancer (n=1).We identified 10 single nucleotide polymorphisms (SNPs) significantly associated with cancer risk: NPAS2 rs10165970 (mixed and breast cancer shiftworkers), rs895520 (mixed), rs17024869 (breast) and rs7581886 (breast); CLOCK rs3749474 (breast) and rs11943456 (breast); RORA rs7164773 (breast and breast cancer postmenopausal), rs10519097 (breast); RORB rs7867494 (breast cancer postmenopausal), PER3 rs1012477 (breast cancer subgroups) and assessed the level of quality evidence to be intermediate.
|
28177907 |
2017 |
|
Malignant neoplasm of breast
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
In women with three consecutive night shifts, a reduced risk of breast cancer was associated with carriage of variant alleles of SNPs in CLOCK (rs3749474), BMAL1 (rs2278749), BMAL2 (rs2306074), CSNK1E (rs5757037), NPAS2 (rs17024926), ROR-b (rs3903529, rs3750420), MTNR1A (rs131113549) and PER3 (rs1012477).
|
23822714 |
2013 |
|
Breast Carcinoma
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
In women with three consecutive night shifts, a reduced risk of breast cancer was associated with carriage of variant alleles of SNPs in CLOCK (rs3749474), BMAL1 (rs2278749), BMAL2 (rs2306074), CSNK1E (rs5757037), NPAS2 (rs17024926), ROR-b (rs3903529, rs3750420), MTNR1A (rs131113549) and PER3 (rs1012477).
|
23822714 |
2013 |
|
Malignant neoplasm of breast
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
The coding region of Per3 gene contains a variable-number tandem-repeat polymorphism, which has been shown to influence bipolar disorder onset and to affect breast cancer risk.
|
21316201 |
2011 |
|
Breast Carcinoma
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
The coding region of Per3 gene contains a variable-number tandem-repeat polymorphism, which has been shown to influence bipolar disorder onset and to affect breast cancer risk.
|
21316201 |
2011 |
|
Malignant neoplasm of breast
|
0.370 |
Biomarker
|
disease |
BEFREE |
Mice deficient in Per3 showed increased susceptibility to breast cancer induced by carcinogen treatment or by overexpression of Erbb2.
|
20625127 |
2010 |
|
Malignant neoplasm of breast
|
0.370 |
Biomarker
|
disease |
CTD_human |
Mice deficient in Per3 showed increased susceptibility to breast cancer induced by carcinogen treatment or by overexpression of Erbb2.
|
20625127 |
2010 |
|
Breast Carcinoma
|
0.370 |
Biomarker
|
disease |
CTD_human |
Mice deficient in Per3 showed increased susceptibility to breast cancer induced by carcinogen treatment or by overexpression of Erbb2.
|
20625127 |
2010 |
|
Breast Carcinoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
Mice deficient in Per3 showed increased susceptibility to breast cancer induced by carcinogen treatment or by overexpression of Erbb2.
|
20625127 |
2010 |
|
Malignant neoplasm of breast
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
We found that the variant Per3 genotype (heterozygous + homozygous 5-repeat alleles) was associated with an increased risk of breast cancer among premenopausal women (odds ratio, 1.7; 95% confidence interval, 1.0-3.0).
|
15668506 |
2005 |
|
Malignant neoplasm of breast
|
0.370 |
Biomarker
|
disease |
BEFREE |
We used immunohistochemical staining, methylation specific PCR and direct sequencing methods to analyze molecular changes in three most important genes, namely PER1, PER2 and PER3, in circadian rhythm in 55 cases of breast cancer of Taiwanese women.
|
15790588 |
2005 |
|
Breast Carcinoma
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
We found that the variant Per3 genotype (heterozygous + homozygous 5-repeat alleles) was associated with an increased risk of breast cancer among premenopausal women (odds ratio, 1.7; 95% confidence interval, 1.0-3.0).
|
15668506 |
2005 |
|
Breast Carcinoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
We used immunohistochemical staining, methylation specific PCR and direct sequencing methods to analyze molecular changes in three most important genes, namely PER1, PER2 and PER3, in circadian rhythm in 55 cases of breast cancer of Taiwanese women.
|
15790588 |
2005 |
|
Bipolar Disorder
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
We found association of ARNTL gene (rs11600996) and PER3 gene (rs228642) polymorphisms with an increased risk of BD/AAD in a group of male patients.
|
30121446 |
2018 |