CCKBR, cholecystokinin B receptor, 887

N. diseases: 105; N. variants: 4
Disease: Colonic Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.060 GeneticVariation group BEFREE Murine deletion of Cck2r abrogated progastrin-dependent increases in colonic proliferation, mucosal thickness, and beta-catenin and CD44 expression in the colon tumor. 19652364 2009
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.060 AlteredExpression group LHGDN The CCK-2/gastrin splice variant receptor retaining intron 4 transactivates the COX-2 promoter in vitro. 17936921 2007
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.060 Biomarker group LHGDN Enhanced expression of cholecystokinin-2 receptor promotes the progression of colon cancer through activation of focal adhesion kinase. 16998832 2006
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.060 AlteredExpression group LHGDN Gastrin suppresses growth of CCK2 receptor expressing colon cancer cells by inducing apoptosis in vitro and in vivo. 16143134 2005
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.060 Biomarker group LHGDN Oncogenic ras induces gastrin/CCKB receptor gene expression in human colon cancer cell lines LoVo and Colo320HSR. 12761477 2003
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.060 Biomarker group BEFREE The short isoform of the CCK-B was detected in 80% of the normal colon tissues, 76.5% of the colon tumors, 100% of the metastasis samples and 75% of the colonic cell lines; whereas the long isoform, which is presumably more strongly activated by gastrin, was expressed in 50% of the normal colon samples, 23% of the colon tumors, 43% of the hepatic metastases and 1 cell line (Sk-Co15). 9296339 1997