|
Inflammatory Bowel Diseases
|
0.310 |
AlteredExpression
|
group |
BEFREE |
VNN1 is expressed by enterocytes and is upregulated in IBD.
|
23949622 |
2013 |
|
Psoriasis
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
We hypothesize that increased levels of pantetheinase activity are part of the inflammatory-regenerative epidermal differentiation program, and may contribute to the phenotype observed in psoriasis.
|
19322213 |
2009 |
|
Psoriasis
|
0.310 |
Biomarker
|
disease |
CTD_human |
We hypothesize that increased levels of pantetheinase activity are part of the inflammatory-regenerative epidermal differentiation program, and may contribute to the phenotype observed in psoriasis.
|
19322213 |
2009 |
|
Inflammatory Bowel Diseases
|
0.310 |
Therapeutic
|
group |
CTD_human |
Thus, the Vanin-1/pantetheinase activity might be a new target for therapeutic intervention in inflammatory bowel disease.
|
17145956 |
2006 |
|
Celiac Disease
|
0.300 |
Biomarker
|
disease |
CTD_human |
Celiac disease biomarkers identified by transcriptome analysis of small intestinal biopsies.
|
30097691 |
2018 |
|
Dermatitis, Atopic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines.
|
19322213 |
2009 |
|
Pustulosis of Palms and Soles
|
0.300 |
Biomarker
|
disease |
CTD_human |
Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines.
|
19322213 |
2009 |
|
Eczema, Infantile
|
0.300 |
Biomarker
|
disease |
CTD_human |
Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines.
|
19322213 |
2009 |
|
Dyslipidemias
|
0.300 |
Biomarker
|
group |
CTD_human |
Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes.
|
17873875 |
2007 |
|
Dyslipoproteinemias
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes.
|
17873875 |
2007 |
|
Hypertensive disease
|
0.030 |
Biomarker
|
group |
BEFREE |
In conclusion, these results suggest that urinary vanin-1 is a potentially sensitive biomarker for ameliorating renal tubular damage in salt-sensitive hypertension.
|
31514290 |
2019 |
|
Renal tubular injury
|
0.030 |
Biomarker
|
disease |
BEFREE |
We have previously demonstrated that urinary vanin-1 is an early biomarker of oxidative renal tubular injury.
|
31514290 |
2019 |
|
Renal tubular injury
|
0.030 |
Biomarker
|
disease |
BEFREE |
Urinary vanin-1 may serve as a candidate biomarker of renal tubular injury due to hydronephrosis.
|
30332759 |
2018 |
|
Colitis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Taken together, our studies suggest that GPRC5a is a potential biomarker for colon cancer and promotes tumorigenesis through stimulation of Vanin-1 expression and oxidative stress in colitis associated cancer.
|
28316092 |
2017 |
|
Colorectal Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
|
28316092 |
2017 |
|
Renal tubular injury
|
0.030 |
Biomarker
|
disease |
BEFREE |
Previously, we found a novel renal biomarker, urinary vanin-1, in several animal models with renal tubular injury.
|
28973979 |
2017 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
A novel transcript, VNN1-AB, as a biomarker for colorectal cancer.
|
24687856 |
2014 |
|
Colitis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In mouse, we examined Vanin-1 expression in gut and feces during dextran sulfate sodium-induced colitis and assayed the effect of PPARg on Vanin-1 regulation.
|
23949622 |
2013 |
|
Hypertensive disease
|
0.030 |
GeneticVariation
|
group |
BEFREE |
We tested the hypothesis that the rs2294757 VNN1 T26I polymorphism could affect blood pressure (BP) levels, hypertension prevalence, and risk of incident cardiovascular events.
|
21550219 |
2013 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
A 7-gene panel (ANXA3, CLEC4D, LMNB1, PRRG4, TNFAIP6, VNN1 and IL2RB) discriminated CRC in the training set (area under the receiver-operating-characteristic curve (ROC AUC), 0.80; accuracy, 73%; sensitivity, 82%; specificity 64%).
|
19795455 |
2010 |
|
Colitis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Recent studies in a mouse colitis model indicated that vanin-1 has proinflammatory activity and suggest that pantetheinases are potential therapeutic targets in inflammatory diseases.
|
19322213 |
2009 |
|
Hypertensive disease
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Further analyses demonstrated that the missense SNP rs2272996 (or N131S) in the VNN1 gene was significantly associated with hypertension in African Americans and the association was replicated in Mexican Americans; a non-significant opposite association was observed in European Americans.
|
18043751 |
2007 |
|
Hypertensive disease
|
0.030 |
GeneticVariation
|
group |
LHGDN |
Further analyses demonstrated that the missense SNP rs2272996 (or N131S) in the VNN1 gene was significantly associated with hypertension in African Americans and the association was replicated in Mexican Americans; a non-significant opposite association was observed in European Americans.
|
18043751 |
2007 |
|
Hydronephrosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
In multivariate analyses, BL vanin-1 and N-acetyl-β-D-glucosaminidase (NAG), but not kidney injury molecule-1 (KIM-1) or neutrophil gelatinase-associated lipocalin (NGAL), were independent factors for predicting the presence of HN.
|
30791405 |
2019 |
|
Glomerulosclerosis (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Fr-STZ DN rats exhibited obvious tubular renal damage and glomerular podocyte injury as confirmed by renal kidney -injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and vanin-1 mRNA, as well as urinary N-acetyl-β-D-glucosaminidase elevation and nephrin mRNA suppression, associated with the appearance of marked renal interstitial fibrosis and glomerulosclerosis despite the absence of microalbuminuria.
|
30699409 |
2019 |