SPHK1, sphingosine kinase 1, 8877

N. diseases: 236; N. variants: 2
Disease: Colonic Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.030 Biomarker group BEFREE First, we show that SphK1 deficient mice significantly attenuated azoxymethane (AOM)-induced colon carcinogenesis as measured by colon tumor incidence, multiplicity, and volume. 29028945 2017
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.030 AlteredExpression group BEFREE Furthermore, overexpression of SphK1 in intestinal epithelial cells significantly enhances AOM-induced colon tumor formation (P < 0.05). 28583134 2017
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.030 AlteredExpression group BEFREE Therefore, we examined the expression of SK1 and COX-2 in rat colon tumors induced by azoxymethane (AOM) and the relationship of these two proteins in normal and malignant intestinal epithelial cells. 16319132 2006