|
Carcinoid Tumor
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The aim of our study was to investigate the correlation of cyclin A2 and B1 expression with prognosis, Ki-67 proliferation index, and carcinoid morphology.
|
31230818 |
2019 |
|
Malignant neoplasm of endometrium
|
0.010 |
Biomarker
|
disease |
BEFREE |
The gene function was evaluated by cell growth curve after knockdown CDC20 and CCNA2 of endometrial cancer cell line.
|
31289358 |
2019 |
|
Malignant tumor of cervix
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ESRP1 Induces Cervical Cancer Cell G1-Phase Arrest Via Regulating Cyclin A2 mRNA Stability.
|
31362365 |
2019 |
|
Peripheral T-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of the CCNA2 gene and CHEK1 protein were associated with poor prognosis in the total nodal PTCL cohort.
|
31497245 |
2019 |
|
Memory impairment
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The specific ablation of cyclin A2 in adult neurons results in neuronal polyribosome aggregations and learning and memory deficits.
|
30579783 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CCNA2 was identified and confirmed as a direct downstream target of miR-219-5p and its expression negatively correlated with miR-219-5p profiles in ESCC tissues.
|
30766610 |
2019 |
|
Cervix carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ESRP1 Induces Cervical Cancer Cell G1-Phase Arrest Via Regulating Cyclin A2 mRNA Stability.
|
31362365 |
2019 |
|
Carcinoid tumor no ICD-O subtype
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The aim of our study was to investigate the correlation of cyclin A2 and B1 expression with prognosis, Ki-67 proliferation index, and carcinoid morphology.
|
31230818 |
2019 |
|
early pregnancy
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We therefore sought to explore the role of CCNA2 in RM and early pregnancy.
|
31087423 |
2019 |
|
cervical cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ESRP1 Induces Cervical Cancer Cell G1-Phase Arrest Via Regulating Cyclin A2 mRNA Stability.
|
31362365 |
2019 |
|
Miscarriage
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of CCNA2 disturbs trophoblast migration, proliferation, and apoptosis during the pathogenesis of recurrent miscarriage.
|
31087423 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The CCNA2 knockdown could significantly suppress CRC cell growth by impairing cell cycle progression and inducing cell apoptosis.
|
30464611 |
2018 |
|
Hepatitis C
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the key genes, cyclin dependent kinase 1 (CDK1), NDC80, cyclin A2 (CCNA2) and rac GTPase activating protein 1 (RACGAP1) were shown to be targeted by the HCV nonstructural proteins NS5A, NS3 and NS5B, respectively.
|
29725417 |
2018 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In univariate analysis for CSS, we found that four of the tested markers, namely high expression of p53 (P = .001), EGFR (P = .003), cyclin A2 (P = .005) and low expression of p16 (P = .019), along with clinical stage (P < .001), tumour size (P < .001), presence of nodal metastasis (P < .001) and perineural permeation (P = .039) were related to decreased survival.
|
29344992 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Significant correlations were detected between LINC00968, miR-9-3p and CCNA2 in lung adenocarcinoma.
|
29805671 |
2018 |
|
Carcinoma, Endometrioid
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also found three additional fusion transcripts involving genes belonging to the cyclin family: ANXA5-CCNA2 and PDE4D-CCNB1 were detected in two endometrioid carcinomas, whereas CCNY-NRG4 was identified in a clear cell carcinoma.
|
29633253 |
2018 |
|
Colon Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Further mechanistic study showed that over-expression of NPTX1 inhibited the expression of cyclin A2 and CDK2 in colon cancer cells, thereby regulating the Rb-E2F signaling.
|
29345391 |
2018 |
|
HIV-1 infection
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Compared to wild-type (WT) SAMHD1, the RL/AA mutant failed to restrict HIV-1 infection and had reduced binding to cyclin A2.
|
29321329 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
CCNA2 acts as a novel biomarker in regulating the growth and apoptosis of colorectal cancer.
|
30464611 |
2018 |
|
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
CCNA2 and PBK of the module and their relative pathway cell‑division cycle, and two subnetworks (pancreatic cancer and intercellular adhesion subnetworks) may be pivotal for further understanding of the molecular mechanism of PC.
|
27035224 |
2016 |
|
Malignant neoplasm of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
CCNA2 and PBK of the module and their relative pathway cell‑division cycle, and two subnetworks (pancreatic cancer and intercellular adhesion subnetworks) may be pivotal for further understanding of the molecular mechanism of PC.
|
27035224 |
2016 |
|
Atrial Septal Defects
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The report about ASD in mice in heterozygous Ccn 1 +/- animals strongly supports this notion.
|
25135600 |
2015 |
|
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To directly test this hypothesis, we generated derivatives of an HCMV-permissive glioblastoma cell line that express cyclin A2 in a constitutive, cell cycle-independent manner.
|
22718829 |
2012 |
|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To directly test this hypothesis, we generated derivatives of an HCMV-permissive glioblastoma cell line that express cyclin A2 in a constitutive, cell cycle-independent manner.
|
22718829 |
2012 |
|
Childhood Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To directly test this hypothesis, we generated derivatives of an HCMV-permissive glioblastoma cell line that express cyclin A2 in a constitutive, cell cycle-independent manner.
|
22718829 |
2012 |