|
Hepatitis B
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Thus, HBV DNA integration in the cyclin A gene resulted in a strong expression of hybrid HBV-cyclin A transcripts encoding a stabilized cyclin A.
|
1321406 |
1992 |
|
Early Hepatocellular Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We have previously reported the identification of a hepatitis B virus (HBV) DNA integration in an intron of the cyclin A gene in an early hepatocellular carcinoma (HCC) and the isolation of human cyclin A cDNA.
|
1321406 |
1992 |
|
Liver carcinoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma.
|
1967822 |
1990 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
As cyclins are important in the control of cell division, the disruption of a cyclin A gene by viral insertion might contribute to tumorigenesis.
|
1967822 |
1990 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
The modification of cyclin A expression in a human liver cancer by the insertion of hepatitis B viral DNA into the cyclin A gene, and binding of cyclin A to the oncogenic E1A viral protein in adenovirus-infected cells suggest that the cyclin is implicated in human carcinogenesis.
|
8384033 |
1993 |
|
Hepatitis B
|
0.040 |
Biomarker
|
disease |
BEFREE |
The cyclin A gene plays an important role in both the S and G2-M phases of the cell cycle, and has been identified at a site of hepatitis B virus DNA integration in a human liver cancer.
|
8530809 |
1995 |
|
Liver neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
We analyzed tumorous and non-tumorous samples from patients with primary liver cancer to determine whether a) the cyclin A gene is rearranged in liver tumors and b) the cyclin A transcript level correlates with the percentage of proliferating cells.
|
8530809 |
1995 |
|
Primary Malignant Liver Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
We analyzed tumorous and non-tumorous samples from patients with primary liver cancer to determine whether a) the cyclin A gene is rearranged in liver tumors and b) the cyclin A transcript level correlates with the percentage of proliferating cells.
|
8530809 |
1995 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The cyclin A gene plays an important role in both the S and G2-M phases of the cell cycle, and has been identified at a site of hepatitis B virus DNA integration in a human liver cancer.
|
8530809 |
1995 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The cyclin A gene plays an important role in both the S and G2-M phases of the cell cycle, and has been identified at a site of hepatitis B virus DNA integration in a human liver cancer.
|
8530809 |
1995 |
|
Malignant neoplasm of liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
The cyclin A gene plays an important role in both the S and G2-M phases of the cell cycle, and has been identified at a site of hepatitis B virus DNA integration in a human liver cancer.
|
8530809 |
1995 |
|
Acute leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Topoisomerase IIalpha gene expression was correlated to cyclin A gene expression in the samples of acute leukemias, Indicating the link of topoisomerase IIalpha expression to the proliferative activity of these leukemic blast cells.
|
8656699 |
1996 |
|
Hepatitis B
|
0.040 |
Biomarker
|
disease |
BEFREE |
We demonstrate that an altered form of cyclin A2 (S2A) which N-terminal part is replaced by the hepatitis B virus envelope protein transforms normal rat kidney cells and cooperates with ras to transform rat embryo fibroblasts.
|
9546429 |
1998 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
We immunohistochemically examined the expression of cyclin A protein in 120 patients with transitional cell carcinoma (TCC) of the renal pelvis and ureter, including adjacent dysplastic lesions to determine their significance for the tumor behavior and patient prognosis.
|
9815824 |
1997 |
|
Carcinoma, Transitional Cell
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We immunohistochemically examined the expression of cyclin A protein in 120 patients with transitional cell carcinoma (TCC) of the renal pelvis and ureter, including adjacent dysplastic lesions to determine their significance for the tumor behavior and patient prognosis.
|
9815824 |
1997 |
|
Acute Promyelocytic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Deregulation of cyclin A2 by RARalpha-PLZF may represent an oncogenic mechanism of this chimeric protein and contribute to the aggressive clinical phenotype of t(11;17)(q23;q21)-associated APL.
|
10023668 |
1999 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Expression levels of cyclin E (P = 0.04) and cyclin A2 (P = 0.004) were significantly higher in the tumor samples than in normal controls.
|
11212263 |
2001 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, cyclin E is a strong independent prognostic indicator in patients with early-stage NSCLC, whereas cyclin E2, cyclin A1, and cyclin A2 do not have a prognostic role in NSCLC.
|
11212263 |
2001 |
|
Chondrosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here we demonstrate that JMC mutations of the PTH/PTHrP receptor induce activation of the cyclin D1 and cyclin A promoters in primary mouse chondrocytes and rat chondrosarcoma cells.
|
12198252 |
2002 |
|
leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Leukemias with a -5/del(5q) have a higher expression of genes involved in cell cycle control (CCNA2, CCNE2, CDC2), checkpoints (BUB1), or growth (MYC), and loss of expression of the gene encoding IFN consensus sequence-binding protein (ICSBP).
|
12417757 |
2002 |
|
Mammary Neoplasms
|
0.030 |
Biomarker
|
group |
LHGDN |
Involvement of G1/S cyclins in estrogen-independent proliferation of estrogen receptor-positive breast cancer cells.
|
12444551 |
2002 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
LHGDN |
Cyclins and cyclin-dependent kinases: comparative study of hepatocellular carcinoma versus cirrhosis.
|
12601350 |
2003 |
|
Fibrosis
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
Cyclins and cyclin-dependent kinases: comparative study of hepatocellular carcinoma versus cirrhosis.
|
12601350 |
2003 |
|
Hepatoblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Efficient gene transfer to hepatoblastoma cells through asialoglycoprotein receptor and expression under the control of the cyclin A promoter.
|
12612447 |
2003 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
In addition, cyclin A2 expression is associated with a poor prognosis in several types of cancer.
|
14510182 |
2003 |