ENDOU, endonuclease, poly(U) specific, 8909

N. diseases: 41; N. variants: 0
Disease: Major Depressive Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.070 PosttranslationalModification disease BEFREE BDNF exon IV and p11 promoter methylation was not associated with test performance.<b>Conclusions:</b> Our results corroborate a concomitant amelioration of executive dysfunctions with successful antidepressant therapy and support a role of BDNF in the neural mechanisms underlying the normalisation of executive dysfunctions in MDD.<b>ClinicalTrials.gov number:</b> NCT00974155; EudraCT: 2008-008280-96. 29334322 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.070 PosttranslationalModification disease BEFREE Next, we investigated the predictive properties of p11 promoter methylation in two clinical cohorts of patients with pharmacoresistant MDD. 29353887 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.070 Biomarker disease BEFREE Furthermore, p11 has been implicated in major depressive disorder (MDD) and in the actions of antidepressants. 27616678 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.070 AlteredExpression disease BEFREE We measured levels of p11 and P2RX7 mRNA in peripheral blood mononuclear cells (PBMCs) of 26 psychiatric patients (11 suicide attempters, 15 suicide non-attempters) with post-traumatic stress disorder (PTSD) and major depressive disorder (MDD), and 14 normal controls, using quantitative real-time PCR. 20863517 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.070 AlteredExpression disease BEFREE We found that patients with PTSD had lower levels of p11 mRNA than control subjects, while those with MDD, BP and SCZ had significantly higher p11 levels than the controls. 19380152 2009
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.070 GeneticVariation disease BEFREE The analysis for genotypic effects showed no significant association between any of the three p11 single nucleotide polymorphisms (SNPs) and MDD therapeutic response. 18838110 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.070 Biomarker disease BEFREE Our results do not support a major role for either common or rare p11 SNPs with MDD. 17510952 2007