|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The survival analysis showed that four lncRNAs (MYCNOS, DLX6-AS1, LINC00221, and CRNDE) and two mRNAs (CCNB1 and SHCBP1) were prognostic biomarkers for patients with HCC in both the TCGA and GEO databases.
|
31007608 |
2019 |
|
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we found that the high level expression of CCNB1 was closely associated with poor prognosis in HCC patients.
|
30651720 |
2019 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The present study indicated that certain miRNAs (including <i>miR-96, miR-145</i> and <i>miR-183</i>) and mRNAs (including <i>NAT2, FBXO5, CCNB1, DEPDC1</i> and <i>NTN4</i>) may be associated with the effects of ribavirin on HCC.
|
29805683 |
2018 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
And it also highlights a FOXM1/CCNB1 axis could be a potential target for the treatment of HCCs.
|
29705704 |
2018 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we demonstrated that specific LXRs agonists downregulated expression of FOXM1, cyclin D1 and cyclin B1 in hepatocellular carcinoma (HCC) cells, which led to cell cycle and cell proliferation arrest.
|
23812424 |
2014 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings show that the upregulation of BMP4 and BMPR1A in HCC promotes the proliferation and metastasis of HCC cells and that CDK1 and cyclin B1 are important SMAD-independent molecular targets in BMP4 signaling pathways, during the HCC tumorigenesis.
|
22241220 |
2012 |
|
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The tumor-associated proteins cyclin B1, Sec62, and Birc3 were highly expressed in a subset of samples of recurrent HCC; cyclin B1, Sec62, and Birc3 positivity was observed in 80%, 65.7%, and 54.2% of the samples, respectively.
|
22682366 |
2012 |
|
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Highest Mybl2, Clusterin, Cdc2, and Cyclin B1 expression occurred in fast progressing DN and HCC of E2f1 transgenics, compared to c-Myc transgenics, and anti-Mybl2 siRNA had highest anti-proliferative and apoptogenic effects in cell lines from HCC of E2f1 transgenics.
|
21419759 |
2011 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings demonstrated that combination of Ad-miR122 with chemotherapeutic agents inhibited HCC cell growth by inducing G2/M arrest and that this arrest is associated, at least in part, with reduced expression of MDR related genes and Cyclin B1.
|
21802841 |
2011 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study also shows that MCM2 and CCNB1 could be promising prognostic and therapeutic targets for HCC.
|
20515845 |
2010 |
|
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These observations were further confirmed in vivo by the reciprocal control of TIS21 expression and FoxM1 phosphorylation in the diethylnitrosamine-induced HCCs and TIS21(-/-) mouse embryonic fibroblast (MEF), in addition to increased expression of cyclin B1 and cdk1 activity.
|
18393292 |
2008 |
|
Polycystic Ovary Syndrome
|
0.310 |
Biomarker
|
disease |
CTD_human |
Progesterone-regulated genes, including mitogen-inducible gene 6 (MIG6), leukemia inhibitory factor (LIF), GRB2-associated binding protein 1 (GAB1), S100P, and claudin-4 were significantly lower in PCOS endometrium; whereas cell proliferation genes, such as Anillin and cyclin B1, were up-regulated.
|
21411543 |
2011 |
|
Polycystic Ovary Syndrome
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Progesterone-regulated genes, including mitogen-inducible gene 6 (MIG6), leukemia inhibitory factor (LIF), GRB2-associated binding protein 1 (GAB1), S100P, and claudin-4 were significantly lower in PCOS endometrium; whereas cell proliferation genes, such as Anillin and cyclin B1, were up-regulated.
|
21411543 |
2011 |
|
Squamous cell carcinoma of the head and neck
|
0.300 |
Biomarker
|
disease |
CTD_human |
Upregulation of cell cycle genes in head and neck cancer patients may be antagonized by erufosine's down regulation of cell cycle processes in OSCC cells.
|
29464035 |
2018 |
|
Sclerocystic Ovaries
|
0.300 |
Biomarker
|
disease |
CTD_human |
Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles.
|
21411543 |
2011 |
|
Diabetes Mellitus, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Significance of insulin signaling in liver regeneration triggered by portal vein ligation.
|
20031167 |
2011 |
|
Hyperplasia
|
0.200 |
Biomarker
|
phenotype |
RGD |
Cellular distributions of molecules with altered expression specific to thyroid proliferative lesions developing in a rat thyroid carcinogenesis model.
|
19298605 |
2009 |
|
Reperfusion Injury
|
0.200 |
Biomarker
|
disease |
RGD |
The expression of cyclins in neurons of rats after focal cerebral ischemia.
|
18278459 |
2008 |
|
Liver Neoplasms, Experimental
|
0.200 |
Biomarker
|
phenotype |
RGD |
Analysis of gene expression in different stages of MeIQx-induced rat hepatocarcinogenesis.
|
17342310 |
2007 |
|
Visual seizure
|
0.200 |
Biomarker
|
disease |
RGD |
Pentylenetetrazole kindling induces neuronal cyclin B1 expression in rat hippocampus.
|
16242239 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, restoration of CCNB1 expression attenuated the tumor‑suppressive effects of miR‑718 overexpression in NSCLC cells.
|
31746372 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Secondly, these PEF protocols were evaluated for the delivery of specific siRNAs targeting the cyclin B1 in subcutaneous tumors in mice.
|
31715364 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cyclin B1/CDK1-regulated mitochondrial bioenergetics in cell cycle progression and tumor resistance.
|
30481564 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, the protein level of hnRNPR in the tumor was positively correlated with the expression of CCNB1 and CENPF in clinical samples.
|
31527303 |
2019 |