|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Biology and targeting of the Jumonji-domain histone demethylase family in childhood neoplasia: a preclinical overview.
|
30759030 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Histone Demethylase JMJD2D Interacts With β-Catenin to Induce Transcription and Activate Colorectal Cancer Cell Proliferation and Tumor Growth in Mice.
|
30472235 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MBD2_v2 and SRSF2 levels were increased in TNBC cell line-derived tumors that formed more frequently in DIO mice relative to tumors in lean control mice.
|
30636104 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
More than 90% of small cell lung cancers (SCLCs) harbor loss-of-function mutations in the tumor suppressor gene <i>RB1</i> The canonical function of the <i>RB1</i> gene product, pRB, is to repress the E2F transcription factor family, but pRB also functions to regulate cellular differentiation in part through its binding to the histone demethylase KDM5A (also known as RBP2 or JARID1A).
|
31727771 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The histone demethylase KDM4B is frequently overexpressed in various cancer types, and previous studies have indicated that the primary oncogenic function of KDM4B is its ability to demethylate H3K9me3 in different tumors, resulting in altered gene expression and genome instability.
|
30459150 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Methyl-CpG binding domain protein 2 (MBD2) is known to act as an epigenetic modulator in various types of tumors; however, the role of MBD2 in lung adenocarcinoma (LUAD) remains unclear.
|
30735628 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This subtype of tumor developed in males had concomitant loss of UTY and KDM6A, suggesting overlapping roles, and points to largely demethylase independent tumor suppressor functions.
|
29533787 |
2018 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
MBD2 deletion also significantly inhibited K562 cell proliferation in a xenograft tumour model in vivo.
|
29565710 |
2018 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
As such, the mammalian lysine-specific demethylase 2 (KDM2) homologs, KDM2A and KDM2B, are either oncogenic or tumor suppressive depending on specific pathological contexts.
|
30233643 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Histone demethylase KDM5A as an oncogene or tumor suppressor in cancer still has been controversial.
|
29324315 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, the study reveals that the X chromosome protects against BCa among females via a <i>KDM6A</i>-dependent epigenetic mechanism and further suggests that <i>KDM6A</i> is a prototypical sex-biasing tumor suppressor with both demethylase-dependent and demethylase-independent activities.
|
29928692 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ALKBH5 (another m<sup>6</sup>A demethylase) has been reported to exert a tumor-promoting function in glioblastoma and breast cancer.
|
29040886 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, the mechanistic experiments indicate that DUXAP10 could interact with Histone demethylase Lysine specific demethylase1 (LSD1) and repress tumor suppressors Large tumor suppressor 2 (LATS2) and Ras-related associated with diabetes (RRAD) transcription in NSCLC cells.
|
28029651 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A histone demethylase-encoding gene PHF2 is considered a putative tumor suppressor gene (TSG).
|
27744626 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The histone demethylase Kdm3a is required for normal epithelial proliferation, ductal elongation and tumor growth in the mouse mammary gland.
|
29156681 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A gene co-expression network identified using TCGA prostate tumour RNA-sequencing identifies co-regulated cancer genes associated with 2-oxoglutarate (2-OG) and succinate metabolism, including TET2, lysine demethylase (KDM) KDM6A, BRCA1-associated BAP1, and citric acid cycle enzymes IDH1/2, SDHA/B, and FH.
|
27819678 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Histone demethylase plant homeodomain (PHD) finger protein 8 (PHF8) has been implicated in tumor development and malignant progression in various types of cancers.
|
28401003 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
KDM6A is a candidate tumor suppressor gene that encodes a histone H3 lysine 27 (H3K27) demethylase.
|
28698146 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, we have determined that the hypoxia-inducible histone demethylase KDM4B is expressed in ∼60% of EOC tumors assayed, including primary and matched metastatic tumors.
|
27869162 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mechanistic investigation reveals that tumor suppressor KLF2 is a key downstream target of lysine-specific demethylase-1 in gastric cancer.
|
28381185 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Multiple histone methyltransferase and demethylase have been implicated as tumor suppressors or oncogenes recently.
|
27034728 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Histone H3 (H3K4) demethylase JARID1B is aberrantly upregulated in many types of tumor and has been proposed to function as oncogene.
|
27584795 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells.
|
27346347 |
2016 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Mbd2 can repress methylated tumor suppressor genes.
|
27073989 |
2016 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Furthermore, TET1 catalytic domain possessed demethylase activity in cancer cells, being able to inhibit the CpG methylation of tumor suppressor gene (TSG) promoters and reactivate their expression, such as SLIT2, ZNF382 and HOXA9.
|
27225590 |
2016 |