Here, we find that the chromatin regulator, JmjC domain histone H3K36me2/me1 demethylase KDM2B, is highly expressed in glioblastoma surgical specimens compared to normal brain.
As the first identified messenger RNA <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) demethylase, FTO has been shown recently to play m<sup>6</sup>A-dependent roles in adipogenesis and tumorigenesis (especially in the development of leukemia and glioblastoma).
Increased expression of the histone H3 lysine 4 methyltransferase MLL4 and the histone H3 lysine 27 demethylase UTX prolonging the overall survival of patients with glioblastoma and a methylated MGMT promoter.
We report that JMJD3, a H3K27me3 demethylase, is induced during differentiation of glioblastoma stem cells (GSCs), where it promotes a differentiation-like phenotype via chromatin dependent (INK4A/ARF locus activation) and chromatin independent (nuclear p53 protein stabilization) mechanisms.