|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Prognostic impact of glioblastoma stem cell markers OLIG2 and CCND2.
|
31568682 |
2020 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Prognostic impact of glioblastoma stem cell markers OLIG2 and CCND2.
|
31568682 |
2020 |
|
Hepatocellular Adenoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, quantitative DNA methylation analysis of LINE-1, RASSF1A, and CCND2 using pyrosequencing was performed in human hepatocellular carcinomas (HCC, n = 40), hepatocellular adenoma (HCA, n = 10), focal nodular hyperplasia (FNH, n = 5), and corresponding peritumoral liver tissues as well as healthy liver tissues (n = 5) from Caucasian patients.
|
31059558 |
2019 |
|
Congenital anomaly of brain
|
0.010 |
Biomarker
|
group |
BEFREE |
The individual presented with a severe brain malformation extending to both brainstem and cerebellum with hypomyelination not previously reported in CCND2-related disorder.
|
31056854 |
2019 |
|
Cystitis glandularis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ultimately, we revealed the role and regulation of UCA1/miR-204/CCND2 regulatory axis in pCGs.
|
30999112 |
2019 |
|
Focal Nodular Hyperplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, quantitative DNA methylation analysis of LINE-1, RASSF1A, and CCND2 using pyrosequencing was performed in human hepatocellular carcinomas (HCC, n = 40), hepatocellular adenoma (HCA, n = 10), focal nodular hyperplasia (FNH, n = 5), and corresponding peritumoral liver tissues as well as healthy liver tissues (n = 5) from Caucasian patients.
|
31059558 |
2019 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, Bmi-1 and Cyclin D2 were found to be positively regulated by USP22, which may have mediated the tumorigenic effects of USP22 in human colon cancer.
|
31612065 |
2019 |
|
Cardiomyopathy, Familial Idiopathic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Importantly, upregulation of Ccnd1 and Ccnd2 suppressed DCM caused by Ttn insufficiency.
|
31705051 |
2019 |
|
Hypoglycemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Hypoglycaemia is common in other overgrowth syndromes but has been described only sporadically in association with PIK3CA and CCND2 variants.
|
28941273 |
2018 |
|
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
Knockdown or pharmacological inhibition of CCND2 by an approved drug significantly impairs leukemic expansion of patient-derived AML cells and engraftment in immunodeficient murine hosts.
|
30300583 |
2018 |
|
Fibroid Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
Silencing of AKT3 and CCND2 drives leiomyoma cell into senescence and cycle arrest.
|
30097674 |
2018 |
|
Uterine Fibroids
|
0.010 |
Biomarker
|
group |
BEFREE |
Silencing of AKT3 and CCND2 drives leiomyoma cell into senescence and cycle arrest.
|
30097674 |
2018 |
|
Congenital contractural arachnodactyly
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
In the present study, the results obtained from our previously published methylation array were analyzed and 10 candidate genes involved in DNA repair [protein phosphatase 4 catalytic subunit (PPP4C)], apoptosis [runt related transcription factor 3 (RUNX3), interferon regulatory factor 4 (IRF4), ubiquitin C‑terminal hydrolase L1 (UCHL1) and tumor protein p53 inducible protein 3 (TP53I3)], cell proliferation [cyclin D2 (CCND2) and Ras association domain family member 1 (RASSF1)], drug metabolism [aldehyde dehydrogenase 1 family member A3 (ALDH1A3) and solute carrier family 29 member 1 (SLC29A1)] and angiogenesis [human immunodeficiency virus‑1 tat interactive protein 2 (HTATIP2)] were selected for quantification of their methylation levels in 54 CCA and 19 adjacent normal tissues using methylation‑sensitive high‑resolution melting.
|
29359783 |
2018 |
|
Impaired cognition
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Schizophrenia-related cognitive dysfunction in the Cyclin-D2 knockout mouse model of ventral hippocampal hyperactivity.
|
30301879 |
2018 |
|
Hyperactive behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Schizophrenia-related cognitive dysfunction in the Cyclin-D2 knockout mouse model of ventral hippocampal hyperactivity.
|
30301879 |
2018 |
|
Metabolic Syndrome X
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
No significant interaction was observed in this study between nutrients (macronutrients, zinc, magnesium and iron) and CCND2 rs11063069 in relation to MetS or its components in this study.
|
29764627 |
2018 |
|
Primary Effusion Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Strong dependencies on cyclin D2 and MCL1 render PEL cell lines highly sensitive to palbociclib and S63845.
|
30111820 |
2018 |
|
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Ph+ ALL cell line SUP-B15 and Ph- ALL cell line Nalm-6 were treated with miR-451a mimic and inhibitor, respectively; proliferation rate was assessed by CCK-8, apoptosis rate was tested by Annexin/PI and the expression levels of Bcl-XL, Bax, cyclin D2 and c-myc were examined by qPCR and western blot (WB).
|
30334451 |
2018 |
|
Idiopathic pulmonary arterial hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
So we try to investigate the effect of miR-29b on Mcl-1 and CCND2 protein in PASMCs, analyze the effect of miR-29b on the proliferation of PASMCs, and explore the significance of miR-29b in the proliferation, apoptosis, and gene therapy of PAH.
|
29662889 |
2018 |
|
Fibrosis, Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, we experimentally confirmed a functional regulatory module containing 5 miRNAs (miR-130b-3p, miR-148a-3p, miR-345-5p, miR-378a-3p, and miR-422a) and 6 genes (COL6A1, COL6A2, COL6A3, PIK3R3, COL1A1, CCND2) associated with liver fibrosis.
|
28919164 |
2017 |
|
Low Grade Endometrial Stromal Sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
NAV2 and CCND2 are novel candidate prognostic markers in LMS and LG-ESS, respectively.
|
28643014 |
2017 |
|
Sarcoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Protein expression by immunohistochemistry of transgelin (TGLN), neuron navigator-2 (NAV2), fatty acid binding protein-3 (FABP3), and cyclin D2 (CCND2) was analyzed in 305 uterine sarcomas (231 LMS, 74 LG-ESS).
|
28643014 |
2017 |
|
LATERAL MENINGOCELE SYNDROME
|
0.010 |
Biomarker
|
disease |
BEFREE |
NAV2 and CCND2 are novel candidate prognostic markers in LMS and LG-ESS, respectively.
|
28643014 |
2017 |
|
LIMB-MAMMARY SYNDROME
|
0.010 |
Biomarker
|
disease |
BEFREE |
NAV2 and CCND2 are novel candidate prognostic markers in LMS and LG-ESS, respectively.
|
28643014 |
2017 |
|
Core binding factor acute myeloid leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mutation assessment of 177 adults with CBF-AML, including 68 with t(8;21) and 109 with inv(16)/t(16;16), identified not only mutations well known in CBF-AML but also mutations in the CCND1 and CCND2 genes, which represent novel frequent molecular alterations in AML with t(8;21).
|
27843138 |
2017 |