Mantle cell lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of cyclin D2, which is rare in MCL, occurred more frequently in DLBCL (11 cases, 10.6%).
|
26985765 |
2016 |
Mantle cell lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The patient was transferred to our hospital, flow cytometry using additional markers showed that the clonal cells were CD200+(dim), CD148+(strong), and chromosome analysis revealed a complex karyotype, 47, XY, t(12;14)(p13;q32), +12, del(9p21), which indicated over-expression of CCND2, and immunostaining showed strong positivity of SOX11 further confirming the characteristics of CCND1-negtive MCL.
|
26261659 |
2015 |
Mantle cell lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this issue of Blood, Salaverria et al report that more than half of Cyclin D1- (CCND1) negative SOX11-positive mantle cell lymphoma (MCL) had CCND2 gene rearrangement predominantly with immunoglobulin (IG) light chain genes.(1)
|
23429984 |
2013 |
Mantle cell lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CCND2 rearrangements are the most frequent genetic events in cyclin D1(-) mantle cell lymphoma.
|
23255553 |
2013 |
Mantle cell lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CD5-positive, cyclinD1-negative mantle cell lymphoma with a translocation involving the CCND2 gene and the IGL locus.
|
21504716 |
2011 |
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Small interfering RNAs targeting cyclin D1 and cyclin D2 enhance the cytotoxicity of chemotherapeutic agents in mantle cell lymphoma cell lines.
|
21745168 |
2011 |
Mantle cell lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In mantle-cell lymphoma, the t(11;14) translocation leads to overexpression of cyclin-D1, in addition to which cyclin-D1-negative mantle-cell lymphoma that overexpress cyclin-D2 or D3 have also been described.
|
20062012 |
2010 |
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
There are rare cyclin D1-negative cases of MCL overexpressing cyclin D2.
|
19783727 |
2009 |
Mantle cell lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cyclin D2 and D3 mRNA levels were significantly higher in cyclin D1-negative mantle cell lymphoma than in conventional mantle cell lymphoma but the protein expression was not discriminative.
|
19880778 |
2009 |
Mantle cell lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We analyzed 4 cases of cycD2(+) mantle cell lymphoma with a translocation involving the CCND2 locus, and its differential diagnosis from 35 mature B-cell non-Hodgkin's lymphomas based on immunohistochemistry, quantitative RT-PCR and FISH analysis.
|
19608671 |
2009 |
Mantle cell lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In sum-mary, this study confirms frequent aberrant expression of cyclin D2 and D3 in t(11;14)-negative MCLs and shows a t(11;14)-independent expression of cy-clin D1 in 25% of present cases.
|
18391076 |
2008 |
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Specific lentiviral shRNA-mediated knockdown of cyclin D1 in mantle cell lymphoma has minimal effects on cell survival and reveals a regulatory circuit with cyclin D2.
|
18685613 |
2008 |
Mantle cell lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Up-regulation of cyclin D2 or D3 may substitute for cyclin D1 in the pathogenesis of MCL.
|
16123218 |
2005 |