Disease: Neuralgia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE ADM_09 is a recently developed lipoic acid-based TRPA1 antagonist that is able to revert oxaliplatin-induced neuropathic pain and inflammatory trigeminal allodynia. 31835593 2019
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE These results indicate that saikosaponins are TRPA1 antagonists and provide a basis for further elaboration of saikosaponin derivatives for the development of new therapeutics for neuropathic pain. 31782210 2019
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE Methylglyoxal could be a mediator of diabetes-induced neuropathic pain through TRPA1 activation and sensitization of the voltage-gated sodium channel subtype 1.8. 31219946 2019
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE The results suggest that injury-induced amygdaloid oxidative stress that drives TRPA1 promotes neuropathic pain behavior. 29274353 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 AlteredExpression phenotype BEFREE Because some non-steroidal anti-inflammatory drugs (NSAIDs) are structural analogs of prostaglandins and NSAIDs attenuate heat nociception and mechanical allodynia in models of inflammatory and neuropathic pain, we investigated whether three widely used NSAIDs (diclofenac, ketorolac, and xefocam) affect thermal and mechanical hyperalgesia following the activation of TRPA1 and TRPV1 channels. 29102918 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE The aim of this study was to evaluate the involvement of TRPA1 channels by means of the antagonist ADM_12 in trigeminal neuropathic pain, in order to identify possible therapeutic targets. 30366396 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE TRPA1 contributed to the neuropathic pain induced by docetaxel treatment. 28370084 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE Notably, Phα1β abated the TRPA1-dependent neuropathic pain-like responses induced by bortezomib. 27759880 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 AlteredExpression phenotype BEFREE Therefore, mmu‑miR‑449a may ameliorate neuropathic pain by decreasing the activity of the channel proteins TRPA1 and KCNMA1 and increasing the levels of TPTE. mmu‑miR‑449a may be a potential therapeutic molecule for the alleviation of neuropathic pain. 28498403 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE Based on localization and functional properties, TRPA1 is considered a key player in acute and chronic (neuropathic) pain and inflammation. 23001121 2012
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE The electrophilic structure of this cytotoxic ketoaldehyde suggests TRPA1, a receptor channel deeply involved in inflammatory and neuropathic pain, as a molecular target. 22740698 2012
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE We conclude from these data that the mechanisms for the induction of cold allodynia in the patients with cold injury are independent of TRPM8 or TRPA1 and differ therefore from neuropathic pain patients. 18440147 2008