SELENBP1, selenium binding protein 1, 8991

N. diseases: 214; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018520
Disease: Halitosis
Halitosis 		0.410 GeneticVariation phenotype BEFREE We identified mutations in SELENBP1 in five patients with cabbage-like breath odor. 29255262 2018
CUI: C0018520
Disease: Halitosis
Halitosis 		0.410 Biomarker phenotype CTD_human We identified mutations in SELENBP1 in five patients with cabbage-like breath odor. 29255262 2018
CUI: C0018520
Disease: Halitosis
Halitosis 		0.410 Biomarker phenotype HPO
CUI: C4748387
Disease: EXTRAORAL HALITOSIS DUE TO METHANETHIOL OXIDASE DEFICIENCY
EXTRAORAL HALITOSIS DUE TO METHANETHIOL OXIDASE DEFICIENCY 		0.400 GeneticVariation disease UNIPROT Mutations in SELENBP1, encoding a novel human methanethiol oxidase, cause extraoral halitosis. 29255262 2018
CUI: C4748387
Disease: EXTRAORAL HALITOSIS DUE TO METHANETHIOL OXIDASE DEFICIENCY
EXTRAORAL HALITOSIS DUE TO METHANETHIOL OXIDASE DEFICIENCY 		0.400 CausalMutation disease CLINVAR
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.350 Biomarker disease BEFREE Our data represent the first peripheral proteomic study of SELENBP1 in schizophrenia and suggest that plasma SELENBP1 protein is downregulated in patients with recent-onset schizophrenia. 29577944 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.350 GeneticVariation disease BEFREE We report a focused study of CN mutations in the selenium binding-protein1 (SELENBP1) locus previously linked with schizophrenia. 20615253 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.350 GeneticVariation disease BEFREE One of four haplotype-tagging SNPs and two different two-marker haplotypes showed nominally significant evidence for association with schizophrenia under an additive model, suggesting that genetic variation in SELENBP1 may influence risk for the disorder, while this significance did not remain when other inheritance models were considered. 19596560 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.350 Biomarker disease CTD_human Future studies should exploit DNA-based methods and molecular investigations on the role of SELENBP1 in order to gain insights into the nature of its influence on schizophrenia and psychotic symptoms. 18163446 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.350 Biomarker disease BEFREE Future studies should exploit DNA-based methods and molecular investigations on the role of SELENBP1 in order to gain insights into the nature of its influence on schizophrenia and psychotic symptoms. 18163446 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.350 Biomarker disease CTD_human Implementing this systematic approach, we: (i) discovered 177 putative SZ risk genes in brain, 28 of which map to linked chromosomal loci; (ii) delineated six biological processes and 12 molecular functions that may be particularly disrupted in the illness; (iii) identified 123 putative SZ biomarkers in blood, 6 of which (BTG1, GSK3A, HLA-DRB1, HNRPA3, SELENBP1, and SFRS1) had corresponding differential expression in brain; (iv) verified the differential expression of the strongest candidate SZ biomarker (SELENBP1) in blood; and (v) demonstrated neuronal and glial expression of SELENBP1 protein in brain. 16223876 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.350 Biomarker disease BEFREE Implementing this systematic approach, we: (i) discovered 177 putative SZ risk genes in brain, 28 of which map to linked chromosomal loci; (ii) delineated six biological processes and 12 molecular functions that may be particularly disrupted in the illness; (iii) identified 123 putative SZ biomarkers in blood, 6 of which (BTG1, GSK3A, HLA-DRB1, HNRPA3, SELENBP1, and SFRS1) had corresponding differential expression in brain; (iv) verified the differential expression of the strongest candidate SZ biomarker (SELENBP1) in blood; and (v) demonstrated neuronal and glial expression of SELENBP1 protein in brain. 16223876 2005
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.330 AlteredExpression disease BEFREE In the CRC cell lines, NaB treatment led to the upregulation of SELENBP1, CEA and AKP when compared with the untreated cells (2.24- to 4.82-fold). 24737289 2014
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.330 Biomarker disease BEFREE Transcriptional regulation and biological functions of selenium-binding protein 1 in colorectal cancer in vitro and in nude mouse xenografts. 19924303 2009
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.330 Biomarker disease CTD_human Expression of selenium-binding protein 1 characterizes intestinal cell maturation and predicts survival for patients with colorectal cancer. 18435490 2008
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.330 AlteredExpression disease BEFREE Expression of selenium-binding protein 1 characterizes intestinal cell maturation and predicts survival for patients with colorectal cancer. 18435490 2008
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.320 Biomarker group CTD_human We identified approximately 3.5-fold significant downregulation of selenium-binding protein 1 (SBP1) in colorectal tumors compared to normal mucosa (p = 0.003). 18435490 2008
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.320 AlteredExpression group BEFREE We identified approximately 3.5-fold significant downregulation of selenium-binding protein 1 (SBP1) in colorectal tumors compared to normal mucosa (p = 0.003). 18435490 2008
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.320 Biomarker group LHGDN We identified approximately 3.5-fold significant downregulation of selenium-binding protein 1 (SBP1) in colorectal tumors compared to normal mucosa (p = 0.003). 18435490 2008
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.320 AlteredExpression disease BEFREE SELENBP1 mRNA and protein was expressed in 100% of normal and ovarian tumors and qRT-PCR confirmed decreased mRNA expression in 80% of ovarian tumors. 18272210 2008
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.320 Biomarker disease CTD_human SELENBP1 mRNA and protein was expressed in 100% of normal and ovarian tumors and qRT-PCR confirmed decreased mRNA expression in 80% of ovarian tumors. 18272210 2008
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.320 Biomarker disease CTD_human In order to develop a better understanding of the role of SELENBP1 in ovarian cancer, our objective was to determine if SELENBP1 is expressed in the normal ovaries and ovarian tumors in the egg-laying hen, a spontaneous model of human ovarian cancer. 18272210 2008
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.320 Biomarker disease BEFREE In order to develop a better understanding of the role of SELENBP1 in ovarian cancer, our objective was to determine if SELENBP1 is expressed in the normal ovaries and ovarian tumors in the egg-laying hen, a spontaneous model of human ovarian cancer. 18272210 2008
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.320 Biomarker group LHGDN Suppression of human selenium-binding protein 1 is a late event in colorectal carcinogenesis and is associated with poor survival. 16645984 2006
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.320 Biomarker disease CTD_human These results suggest that changes of SELENBP1 expression in malignant ovarian cancer are an indicator of aberration of selenium/androgen pathways and may reveal prognostic information of ovarian cancer. 16380993 2006