|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Participants with hypertension but without diabetes (N = 1167) were randomized to an SBP target below 120 mm Hg (intensive treatment) vs a target below 140 mm Hg (standard treatment).
|
31840813 |
2020 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Higher concentrations of TXB2 (P = 0.0223) and higher SBP (P = 0.0063) were found with diabetes (versus non-diabetic) in PIA1/A1 homozygotes.
|
31356179 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We analyzed OH measurements from the Action to Control Cardiovascular Risk in Diabetes BP trial, which evaluated two blood pressure (BP) goals (systolic BP [SBP] < 120 mm Hg vs. SBP < 140 mm Hg) and incident CVD among adults with diabetes and hypertension.
|
30715100 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We analyzed outcome in 4005 treated hypertensive patients (22% obesity, 8% diabetes and 21% current smoking habit) with target attended office SBP less than 140 mmHg, in relation to quintiles of DBP, cardiovascular risk profile and target organ damage (LV hypertrophy, carotid plaque and left atrial dilatation).
|
31205199 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whether SBP VVV is also a predictor of CKD development in diabetes is currently uncertain.
|
30624364 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whether SBP VVV is also a predictor of CKD development in diabetes is currently uncertain.
|
30817462 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The mean SBP greater than 120 mmHg had higher prevalence of cardiovascular risk factors, such as diabetes (38.4 vs. 27.2%, P = 0.001), hypertension (58.8 vs. 32.4%, P < 0.001), and chronic kidney disease (3.3 vs. 1.0%, P = 0.043) than mean SBP 120 mmHg or less.
|
31045965 |
2019 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hazard ratios and 95% confidence intervals were estimated for the associations of variability in SBP with risk of diabetes nephropathy by using Cox proportional hazards regression models.
|
30640884 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
TRH patients (61% women) were older (70 vs. 66 years), had higher SBP (152 vs. 141 mmHg) and more diabetes (30 vs. 20%) (P < 0.001 for all) compared with HTN patients.Mean follow-up time was 4.3 years.
|
28957848 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
SBP ≥140 mmHg (OR = 0.78; 95% CI: 0.65-0.95), DBP ≥90 mmHg (OR = 0.71; 95% CI: 0.58-0.88), and a positive family history of diabetes (OR = 0.77; 95% CI: 0.66-0.9) were found as protective factors against zero or five EDP in blood pressure recording the male gender (OR = 1.18; 95% CI: 1.04-1.35) was found to be its independent risk factor.
|
29137464 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Orthostatic hypotension-related hospitalizations were predicted by age [per 1-year increase, hazard ratio 1.14, 95% confidence interval (CI): 1.12-1.16], smoking (hazard ratio 1.35, 95% CI: 1.12-1.64), diabetes (hazard ratio 1.50, 95% CI: 1.00-2.25), baseline orthostatic hypotension (hazard ratio 1.45, 95% CI: 1.05-1.98), in particular, by SBP fall at least 30 mmHg (hazard ratio 3.93, 95% CI: 2.14-7.23), whereas syncope hospitalizations by age (per 1-year increase, hazard ratio 1.09, 95% CI: 1.07-1.11), smoking (hazard ratio 1.27, 95% CI: 1.08-1.49), and hypertension (hazard ratio 1.42, 95% CI: 1.20-1.69).
|
28009704 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Baseline measurements and changes in HbA<sub>1c</sub> and SBP a year after diagnosis of diabetes through screening independently associate with new onset albuminuria 4 years later.
|
28029211 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the other hand, in patients at a high level of cardiovascular risk, the presence of diabetes (29 RCTs, 52 350 patients) was associated with a significantly smaller outcome benefit of a standardized BP lowering to SBP less than 130 mmHg, and the opposite was found in absence of diabetes (22 RCTs, 102 792 patients).
|
28858983 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In multivariate regression analysis prehemodialysis SBP, age and diabetes were independently associated with increased SBP ARV.
|
28806350 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hemoglobin A1c (HbA1c) for the diabetes cohort, systolic and diastolic blood pressure (SBP and DBP, respectively) for the hypertension cohort, and low-density lipoprotein (LDL) for the hyperlipidemia cohort.
|
28374214 |
2017 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Generalized linear models were used to assess whether variation at -344C/T associated with plasma aldosterone concentration (PAC), systolic and diastolic blood pressure (SBP and DBP), plasma glucose (in persons with no diabetes), HOMA IR (Homeostasis Model Assessment as an Index of Insulin Resistance), and left ventricular (LV) mass indexed to height.
|
26200036 |
2015 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Logistic analysis confirmed that diabetes duration (odds ratio (OR) 1.108, P<0.01), SBP (OR 1.022, P<0.05), HbA1c (OR 1.267, P<0.05), and the VDR rs2228570 T allele (OR 1.467, P<0.01) were independently associated with DR risk.
|
25899017 |
2015 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Risk alleles of the TCF7L2 gene showed increased risk of diabetes even when controlled for traditional diabetes risk factors (diabetes in family, waist circumference, physical activity, BMI, SBP and total and HDL-cholesterol) in both a cross-sectional and prospective setting (cross-sectional: rs12255372 OR 1.61 (1.31-1.99), rs7903146 OR 1.48 (1.20-1.83) and prospective: rs12255372 OR 1.59 (1.22-2.07), rs7903146 OR 1.47 (1.11-1.93)).
|
18972257 |
2009 |