ACVR1, activin A receptor type 1, 90

N. diseases: 144; N. variants: 15
Disease: Stromal Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0879615
Disease: Stromal Neoplasm
Stromal Neoplasm 		0.010 Biomarker disease BEFREE We found that 1) STIP1 protein on the extracellular surface of tumor cells promoted the proliferation and migration/invasion of RCC tumor cells through the autocrine STIP1-ALK2-SMAD1/5 pathway; and 2) STIP1 protein secreted into the extracellular tumor stromal area, promoted the differentiation of osteoclasts through the paracrine STIP1-PrPc-ERK1/2 pathway. 28199984 2017