HAP1, huntingtin associated protein 1, 9001

N. diseases: 65; N. variants: 2
Disease: Hypertensive disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.040 Biomarker group BEFREE We show that transgenic animals containing Hap-I have increased blood pressure compared with those containing Hap-II. 31201268 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.040 Biomarker group BEFREE Since Hap-I of the human AT1R gene is associated with hypertension in Caucasians, we generated transgenic (TG) mice with Hap-I and Hap-II and studied the physiological significance of high fat diet (HFD) on haplotype specific gene expression. 29036458 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.040 GeneticVariation group BEFREE Hap-I of AT1R gene is associated with hypertension in Caucasians. 30084918 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.040 GeneticVariation group BEFREE In vivo, a case-control study demonstrated that homozygosity for Hap I doubled the risk for hypertension in a Chinese population, even after adjustment for risk factors including age, gender, and body mass index. 18235092 2008