SEMA5A, semaphorin 5A, 9037

N. diseases: 85; N. variants: 24
Disease: Malignant neoplasm of pancreas ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.050 Biomarker disease BEFREE Semaphorin 5A has been linked to tumor growth, invasion, and metastasis in pancreatic cancer. 29977159 2018
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.050 AlteredExpression disease BEFREE We have also demonstrated that SEMA5A has a constitutive expression in PC cell lines derived from metastatic sites in comparison with low endogenous expression in the primary tumor-derived cell line. 30577767 2018
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.050 GeneticVariation disease BEFREE We utilized human tissue microarrays and different PC mouse models (Pdx1-cre; LSL- Kras<sup>(G12D)</sup>, Pdx1-Cre; LSL-Kras<sup>(G12D)</sup>; LSL-p53<sup>(R172H)</sup> and RIP1-Tag2) to analyze SEMA5A expression during PC progression. 29464045 2018
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.050 AlteredExpression disease BEFREE Our earlier reports demonstrated that membrane-bound semaphorin 5A (SEMA5A) is expressed in aggressive pancreatic cancer cells and tumours, and promotes tumour growth and metastasis. 22782341 2012
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.050 AlteredExpression disease BEFREE High gene expression of semaphorin 5A in pancreatic cancer is associated with tumor growth, invasion and metastasis. 20073063 2010