|
Diabetes Mellitus, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor b expression in diabetic rat liver.
|
20828602 |
2011 |
|
HIV Infections
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Additionally, when comparing infected p24+ cells to bystander uninfected p24- cells (after bulk HIV infections), HIV replication significantly increased T cell activation (CD69, CD25, HLA.DR, CD38, and Ki67) without concomitantly increasing CycT1 protein levels, possibly due to hijacking of P-TEFb by the viral Tat protein.
|
30786885 |
2019 |
|
HIV Infections
|
0.040 |
Biomarker
|
group |
BEFREE |
This study provides evidence that HIV infection of cells occurs in the vagina of mice expressing human CD4, CCR5, and Cyclin T1 and that HSV-2 infection increases HIV infection.
|
19886831 |
2009 |
|
HIV Infections
|
0.040 |
Biomarker
|
group |
LHGDN |
Increased in vivo activation of microglia and astrocytes in the brains of mice transgenic for an infectious R5 human immunodeficiency virus type 1 provirus and for CD4-specific expression of human cyclin T1 in response to stimulation by lipopolysaccharides.
|
18353948 |
2008 |
|
HIV Infections
|
0.040 |
Biomarker
|
group |
BEFREE |
Cyclin T1 can be reinduced by pathogen-associated molecular patterns (PAMPs) or HIV infection.
|
16330531 |
2006 |
|
Malignant transformation
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Cyclin T1 overexpression induces malignant transformation and tumor growth.
|
20714219 |
2010 |
|
Malignant transformation
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
These preliminary results suggest that the Cdk9/Cyclin T1 complex may be important in the activation and differentiation program of lymphoid cells and that its upregulation, which is due to still unknown mechanisms, may contribute to malignant transformation.
|
17352406 |
2007 |
|
Malignant transformation
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
The molecular mechanism through which the CDK9/CYCLIN T1 complex is altered in malignant transformation needs to be elucidated.
|
15258998 |
2004 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Nu/nu mice s.c. injected with stable transfected Cyclin T1 cells (NIH 3T3 Cyclin T1) developed tumors faster than animals injected with control cells (NIH 3T3 beta-gal).
|
20714219 |
2010 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
In addition, the expression of Cdk9 and Cyclin T1 was evaluated by immunohistochemistry in samples of neuroblastoma, PNET (Primary Neuroectodermal Tumor) and astrocytoma tumors of different grades, in order to assess whether there was a correlation between Cdk9 expression and tumor grading.
|
15753651 |
2005 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
CDK9/Cyclin T1 kinase is a protein kinase, indirectly involved in the cell cycle progression in the form of transcription elongation, CDK9 specific inhibitors may be a potential alternative treatment not only for cancer but also other life-threatening diseases.
|
31603123 |
2020 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
CDK9/Cyclin T1 kinase is a protein kinase, indirectly involved in the cell cycle progression in the form of transcription elongation, CDK9 specific inhibitors may be a potential alternative treatment not only for cancer but also other life-threatening diseases.
|
31603123 |
2020 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Aberrant expression of CDK9/cyclin T1 has been found in diffuse large B-cell lymphoma, and suggest that CDK9 seems to be a potential therapeutic target for diffuse large B-cell lymphoma.
|
31289198 |
2019 |
|
Adult Diffuse Large B-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Aberrant expression of CDK9/cyclin T1 has been found in diffuse large B-cell lymphoma, and suggest that CDK9 seems to be a potential therapeutic target for diffuse large B-cell lymphoma.
|
31289198 |
2019 |
|
Vascular calcification
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These results demonstrate that the CDK9-cyclin T1 and CDK9-cyclin T2/K complexes have opposing roles in CHOP expression and CKD-induced vascular calcification.
|
30209133 |
2018 |
|
Chronic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
These results demonstrate that the CDK9-cyclin T1 and CDK9-cyclin T2/K complexes have opposing roles in CHOP expression and CKD-induced vascular calcification.
|
30209133 |
2018 |
|
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
Graphical abstract Graphic representation of dual-antibody-conjugated chitosan nanoparticles for the targeted delivery of siRNA across the blood-brain barrier (BBB) for inhibiting HIV replication in astrocytes. a Nanoparticle delivery to the BBB and penetration. b TfR-mediated transcytosis of nanoparticles across the epithelial cells. c B2R-mediated endocytosis of nanoparticles in astrocytes. d The molecular interactions between HIV-1 Tat protein and Cyclin T1 and Tip110 cellular proteins. e A schematic representation of chitosan nanoparticles with its components.
|
28315051 |
2017 |
|
NUT midline carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline carcinoma (NMC) cells are specifically killed by CDK9 inhibition (CDK9i) and depend on CDK9 and Cyclin-T1 expression.
|
28930680 |
2017 |
|
HIV-1 infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Current strategies for a functional cure of HIV-1 infection therefore are likely to require development of latency reversal agents that up-regulate CDK9 and Cyclin T1 function in resting CD4+ T cells.
|
28677507 |
2017 |
|
Tuberculosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MTB induced the expression of CycT1 and HIV-1 gag/pol mRNA in both PFMCs from HIV/TB subjects and MN from HIV-1-infected subjects.
|
21453127 |
2012 |
|
Multiple Chronic Conditions
|
0.010 |
Biomarker
|
disease |
BEFREE |
Multi-labelling confocal laser-scanning microscopy revealed that CDK9 and cyclin T1 co-localized perfectly with pUL69 in individual speckles.
|
21450947 |
2011 |
|
Influenza
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we report that cyclin T1/CDK9 can interact with influenza virus polymerase and facilitate its association with cellular Pol II.
|
20943989 |
2010 |
|
Influenza A
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cyclin T1/CDK9 interacts with influenza A virus polymerase and facilitates its association with cellular RNA polymerase II.
|
20943989 |
2010 |
|
Cytomegalovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Recruitment of cdk9 to the immediate-early viral transcriptosomes during human cytomegalovirus infection requires efficient binding to cyclin T1, a threshold level of IE2 86, and active transcription.
|
19297489 |
2009 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.010 |
Biomarker
|
disease |
BEFREE |
These complexes contain cyclin-dependent kinase 9 as the catalytic subunit and different cyclin subunits-cyclin T1, T2a, T2b, or K. Cyclin T1 is targeted by the human immunodeficiency virus (HIV) Tat protein to activate transcription of the HIV provirus.
|
16330531 |
2006 |