CLDN1, claudin 1, 9076

N. diseases: 192; N. variants: 4
Disease: Non-Small Cell Lung Carcinoma ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.060 AlteredExpression disease BEFREE This enabled (i) targeting of the most frequent endocrine malignancy, namely, Cldn1-overexpressing thyroid cancer, and (ii) improved targeting of the most common cancer type worldwide, non-small cell lung cancer (NSCLC), which is characterized by high expression of several claudins, including Cldn1 and Cldn5. 31825142 2020
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.060 Biomarker disease BEFREE TUSC3 accelerates cancer growth and induces epithelial-mesenchymal transition by upregulating claudin-1 in non-small-cell lung cancer cells. 30098333 2018
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.060 AlteredExpression disease BEFREE RESULTS Increased CLDN1 expression promoted the development and metastasis of NSCLC. 28614291 2017
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.060 Biomarker disease BEFREE Claudin-1 Protein Expression Is a Good Prognostic Factor in Non-Small Cell Lung Cancer, but only in Squamous Cell Carcinoma Cases. 27687058 2017
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.060 AlteredExpression disease BEFREE CLDN1 is a novel target of miR-375, and high miR-375 expression shortens survival in NSCLC. 25001509 2014
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.060 AlteredExpression disease BEFREE Our results suggest that the expression of CLDN1 and IGF2 indicate a poor prognosis in stage N2 NSCLC. 24112161 2013