|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
DIRAS3 is an imprinted tumor suppressor gene that encodes a 26 kD GTPase with homology to RAS that inhibits cancer cell proliferation and motility.
|
31003488 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
DIRAS3 is a tumor suppressor gene downregulated in >60% of primary ovarian cancers by genetic, epigenetic, transcriptional and post-transcriptional mechanisms, that upon re-expression can induce autophagy and dormancy in a xenograft model of ovarian cancer.
|
31052266 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ARHI is a remarkable tumor suppressor gene in human ovarian cancer and many other cancers.
|
31088402 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
DIRAS3 is a maternally imprinted tumor suppressor gene, located on chromosome 1p31, and implicated in growth and oncogenesis.
|
30916492 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Re-expression of the imprinted tumor suppressor gene DIRAS family GTPase 3 (DIRAS3) (aplysia ras homology member I [ARHI]) induces autophagy and tumor dormancy in ovarian cancer xenografts, but drives autophagic cancer cell death in cell culture.
|
30620384 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Previously reports showed that DIRAS3 inhibits cell proliferation and induces autophagy in ovarian, breast, lung and prostate cancers, which is heterozygosity loss or down-regulated in aforementioned cancers and functionally as a tumor suppressor, whereas the role of DIRAS3 in glioma is still veiled.
|
30266404 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
DIRAS3 is downregulated in many tumor types, including ovarian cancer, where re-expression inhibits cancer cell growth, reduces motility, promotes tumor dormancy and induces macroautophagy/autophagy.
|
29368982 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Overexpression of DIRAS3 in BGC-823 cells elevated autophagy levels in subcutaneous xenograft and inhibited tumor growth in mice; the hematogenous liver and lung metastasis of cancer cells were also suppressed.
|
30043279 |
2018 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
We therefore reasoned that ARHI is a novel epigenetic silenced tumor suppressor gene on chromosome 1p that is involved in sporadic PCC tumorigenesis.
|
29156798 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ARHI is an imprinted tumor suppressor gene and its methylation suppresses ARHI transcription levels to cause the development and progression of malignant tumors.
|
27685841 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ARHI (DIRAS3), an imprinted tumor suppressor gene, is downregulated in 60% of ovarian cancers.
|
26247722 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ARHI, an imprinted tumor-suppressor gene, is markedly down-regulated or even undetectable in the majority of EOC.
|
25077680 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Functional inhibition of autophagy with choroquine in dormant xenografts that express DIRAS3 significantly delays tumor regrowth after DIRAS3 levels are reduced, suggesting that autophagy sustains dormant ovarian cancer cells.
|
24879154 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, these results suggest that ARHI acts as a tumor suppressor gene in MDA-MB-231 cells and, although TSA+DAC can block the cells at different cell cycle phage, the antitumor effect is ARHI-dependent.
|
24676336 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ARHI is a Ras-related imprinted tumor-suppressor gene that inhibits cancer cell growth and motility.
|
23604529 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ARHI is an imprinted tumor-suppressor gene that is downregulated in >60% of ovarian cancers, and its loss is associated with decreased progression-free survival.
|
21643014 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, a significant correlation between the level of ARHI protein expression and the degree of tumor differentiation and Tumor-Node-Metastasis stage was observed (P < 0.05).
|
22497484 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ARHI is a novel tumor suppressor gene located on chromosome 1p31.
|
22427032 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, ARHI is a tumor suppressor gene downregulated in prostate cancer, and overexpression of ARHI can inhibit cell proliferation, colony formation, and invasion.
|
21071579 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our current observations provide evidences that ARHI downregulated in HCCs could play a role in liver cancer via acting as a tumor suppressor gene, which mainly was triggered by the epigenetic events in HCC specimens.
|
18612997 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The maternally imprinted Ras-related tumor suppressor gene aplasia Ras homolog member I (ARHI; also known as DIRAS3) is downregulated in more than 60% of ovarian cancers, and here we show that re-expression of ARHI in multiple human ovarian cancer cell lines induces autophagy by blocking PI3K signaling and inhibiting mammalian target of rapamycin (mTOR), upregulating ATG4, and colocalizing with cleaved microtubule-associated protein light chain 3 (LC3) in autophagosomes.
|
19033662 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, our data suggest DIRAS3 as a novel, prognostically relevant candidate gene that is frequently methylated and silenced in oligodendroglial tumors with 1p deletion.
|
18302158 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Multiple histone deacetylases repress tumor suppressor gene ARHI in breast cancer.
|
17230502 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Transcriptional and posttranscriptional down-regulation of the imprinted tumor suppressor gene ARHI (DRAS3) in ovarian cancer.
|
16638845 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Taken together, our results suggest that E2F1, 4 and their complexes with HDAC play an important role in downregulating the expression of the tumor suppressor gene ARHI in breast cancer cells.
|
16158053 |
2006 |