Increased serum levels of IL-33 is related with keeping cats during pregnancy and in early childhood and can be associated with the development of asthma in children.
Moreover, neonatal mice were protected from AHR when inhaled <i>Acinetobacter lwoffii</i> (an environmental bacterial isolate found in cattle farms, which is known to protect from childhood asthma) was administered concurrent with HDM.<i>A. lwoffii</i> blocked the expansion of pulmonary IL-13<sup>+</sup>CD4<sup>+</sup> T cells, whereas IL-13<sup>+</sup> ILCs and IL-33 remained elevated.Administration of <i>A. lwoffii</i> mirrored the findings from the CD4<sup>cre</sup>IL-13 KO mice, providing a translational approach for disease protection in early life.