|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Waist-Hip Ratio
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of schizophrenia in Ashkenazi Jews.
|
26198764 |
2015 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Human tumorous imaginal disc (Tid1), a DnaJ co-chaperone protein, is classified as a tumor suppressor.
|
30083263 |
2018 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
In this study, we show that the tumor suppressor Tid1 forms a complex with p53 under hypoxic conditions that directs p53 translocation to the mitochondria and the subsequent initiation of the mitochondrial apoptosis pathway.
|
19935715 |
2010 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Recently, we identified htid-1, the human counterpart of the Drosophila tumor suppressor gene lethal(2)tumorous imaginal discs [l(2)tid], as a direct molecular ligand of the adenomatous polyposis coli (APC) tumor suppressor.
|
18097612 |
2008 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
The Ptch polymorphism affects Hras-induced apoptosis, and binding to Tid1, the mouse homologue of the Drosophila l(2)tid tumour suppressor gene.
|
17230190 |
2007 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth.
|
15601829 |
2005 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Tid1 is the human homologue of the Drosophila tumor suppressor, Tid56.
|
16204048 |
2005 |
|
Neoplasms
|
0.070 |
GeneticVariation
|
group |
BEFREE |
We report the first case of a tumor-associated mutation at the human TID1 locus, which was identified in the SF767 glioma cell line giving rise to aberrantly high levels of a hTid-1(L) mutant variant.
|
15589840 |
2004 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Previously, we demonstrated that Tid1 reduces head and neck squamous cell carcinoma (HNSCC) malignancy.
|
30083263 |
2018 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Previously, we demonstrated that Tid1 reduces head and neck squamous cell carcinoma (HNSCC) malignancy.
|
30083263 |
2018 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Tid1 is a new regulator of p53 mitochondrial translocation and apoptosis in cancer.
|
19935715 |
2010 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Tid1 is a new regulator of p53 mitochondrial translocation and apoptosis in cancer.
|
19935715 |
2010 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Expression of EIF3-p48/INT6, TID1 and Patched in cancer, a profiling of multiple tumor types and correlation of expression.
|
17385060 |
2007 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Expression of EIF3-p48/INT6, TID1 and Patched in cancer, a profiling of multiple tumor types and correlation of expression.
|
17385060 |
2007 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The roles of Tid1-interacting client proteins in metastasis were validated both in <i>vitro</i> and in <i>vivo</i>.
|
30083263 |
2018 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, Tid1 abolished the nuclear translocation of Galectin-7 and suppressed Galectin-7-induced tumorigenesis and metastasis.
|
30083263 |
2018 |
|
Cardiomyopathy, Familial Idiopathic
|
0.020 |
Biomarker
|
disease |
BEFREE |
Tid1 also plays a major role in preventing DCM; however, the role of Tid1 in isoproterenol (ISO)-induced cardiac apoptosis and hypertrophy remains unclear.
|
30443176 |
2018 |
|
Adenomatous Polyposis Coli
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
These changes concerned both the localization and the expression level of all three htid-1 splice variants and of APC.
|
18097612 |
2008 |
|
Adenomatous Polyposis Coli
|
0.020 |
Biomarker
|
disease |
LHGDN |
Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC.
|
17588722 |
2007 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
These findings suggest potential integrated roles for INT6, TID1, and Patched proteins in cell growth, development, and tumorigenesis.
|
17385060 |
2007 |
|
Cardiomyopathy, Familial Idiopathic
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that Dnaja3 is crucial for mitochondrial biogenesis, at least in part, through its chaperone activity on Polga and provide genetic evidence of the necessity for mitochondrial Hsp40 in preventing DCM.
|
16327803 |
2006 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
LHGDN |
Together, these results indicate that Tid1 negatively regulates the motility and metastasis of breast cancer cells, most likely through attenuation of nuclear factor kappaB activity on the promoter of the IL8 gene.
|
16204048 |
2005 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Together, these results indicate that Tid1 negatively regulates the motility and metastasis of breast cancer cells, most likely through attenuation of nuclear factor kappaB activity on the promoter of the IL8 gene.
|
16204048 |
2005 |