ESAM, endothelial cell adhesion molecule, 90952

N. diseases: 24; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.300 Biomarker disease CTD_human Exome sequencing supports a de novo mutational paradigm for schizophrenia. 21822266 2011
CUI: C2985280
Disease: Blood Protein Measurement
Blood Protein Measurement 		0.100 GeneticVariation phenotype GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.030 AlteredExpression disease BEFREE Endothelial cell-selective adhesion molecule (ESAM) is expressed exclusively in platelets and endothelial cells, and soluble ESAM (sESAM) levels have been associated with prevalent subclinical atherosclerosis. 28888270 2017
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.030 AlteredExpression disease BEFREE Endothelial cell-selective adhesion molecule (ESAM) is expressed exclusively in platelets and endothelial cells, and soluble ESAM (sESAM) levels have been associated with prevalent subclinical atherosclerosis. 28888270 2017
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.030 GeneticVariation disease BEFREE This study aimed to investigate the association of both intercellular adhesion molecule-1 (ICAM-1) and endothelial cell adhesion molecule (E-selectin) polymorphisms using PCR technique and their role in the pathogenesis of atherosclerosis. 22648254 2012
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.030 GeneticVariation disease BEFREE This study aimed to investigate the association of both intercellular adhesion molecule-1 (ICAM-1) and endothelial cell adhesion molecule (E-selectin) polymorphisms using PCR technique and their role in the pathogenesis of atherosclerosis. 22648254 2012
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.030 AlteredExpression disease BEFREE In this study, we assessed the effects of ESAM inactivation on atherosclerosis in mice. 20406651 2010
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.030 AlteredExpression disease BEFREE In this study, we assessed the effects of ESAM inactivation on atherosclerosis in mice. 20406651 2010
CUI: C0002871
Disease: Anemia
Anemia 		0.010 GeneticVariation disease BEFREE Approximately half of ESAM-null fetuses died after mid-gestation due to anemia. 31813828 2019
CUI: C0006287
Disease: Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia 		0.010 Biomarker disease BEFREE Although hyperoxic exposure reduces an endothelial cell marker platelet and endothelial cell adhesion molecule but increases a mesenchymal cell biomarker α-smooth muscle actin in vitro in human pulmonary endothelial cells, there is no direct evidence showing EndoMT in the development of bronchopulmonary dysplasia. 31251941 2019
CUI: C1561643
Disease: Chronic Kidney Diseases
Chronic Kidney Diseases 		0.010 Biomarker group BEFREE ESAM was higher in patients with CKD than in those without CKD (p = 0.02), adiponectin, ICAM1, and VEGF were similar. 29804241 2018
CUI: C0003811
Disease: Cardiac Arrhythmia
Cardiac Arrhythmia 		0.010 Biomarker phenotype BEFREE As such, serum sVCAM-1 may be used as a predictive biomarker for this common arrhythmia. 28821262 2017
CUI: C0003857
Disease: Congenital arteriovenous malformation
Congenital arteriovenous malformation 		0.010 AlteredExpression disease BEFREE In vivo imaging of endothelial cell adhesion molecule expression after radiosurgery in an animal model of arteriovenous malformation. 28949989 2017
CUI: C0332853
Disease: Anastomosis
Anastomosis 		0.010 Biomarker disease BEFREE We have compared the contribution of two endothelial cell-specific adhesion proteins, VE-cadherin (VE-cad/Cdh5) and Esama (endothelial cell-selective adhesion molecule a), during angiogenic sprouting and blood vessel fusion (anastomosis) in the zebrafish embryo by genetic analyses. 28264837 2017
CUI: C0334533
Disease: Arteriovenous hemangioma
Arteriovenous hemangioma 		0.010 AlteredExpression disease BEFREE In vivo imaging of endothelial cell adhesion molecule expression after radiosurgery in an animal model of arteriovenous malformation. 28949989 2017
CUI: C3665365
Disease: Arteriosclerotic cardiovascular disease, NOS
Arteriosclerotic cardiovascular disease, NOS 		0.010 Biomarker disease BEFREE sESAM but not sICAM-1 or sVCAM-1 levels are associated with incident ASCVD. 28888270 2017
CUI: C0021051
Disease: Immunologic Deficiency Syndromes
Immunologic Deficiency Syndromes 		0.010 Biomarker group BEFREE Multipotent colony-forming units and long-term hematopoietic-reconstituting cells in immunodeficient mice were found exclusively in the ESAM(High) fraction of CD34(+)CD38(-) cells. 26774386 2016
CUI: C0023418
Disease: leukemia
leukemia 		0.010 Biomarker disease BEFREE Furthermore, KG-1a myeloid leukemia cells switched from ESAM negative to ESAM positive with repeated leukemia reconstitution in vivo. 26774386 2016
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.010 Biomarker disease BEFREE Furthermore, KG-1a myeloid leukemia cells switched from ESAM negative to ESAM positive with repeated leukemia reconstitution in vivo. 26774386 2016
CUI: C0032285
Disease: Pneumonia
Pneumonia 		0.010 AlteredExpression disease BEFREE Here we use VCAM-targeted QDs in a mouse model to show that NOX2, specifically endothelial NOX2, induces VCAM expression with lung inflammation in vivo. 24318114 2014
CUI: C3714636
Disease: Pneumonitis
Pneumonitis 		0.010 AlteredExpression disease BEFREE Here we use VCAM-targeted QDs in a mouse model to show that NOX2, specifically endothelial NOX2, induces VCAM expression with lung inflammation in vivo. 24318114 2014
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.010 Biomarker disease BEFREE Endothelial cell adhesion molecule CD146: implications for its role in the pathogenesis of COPD. 23649916 2013
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.010 Biomarker phenotype BEFREE In this study, we aimed to further elucidate the role of ESAM in tumor metastasis through angiogenic processes. 20153339 2010
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 Biomarker group BEFREE The microvascular density in the tumor was also lower in ESAM-/- than in ESAM+/+ mice. 20153339 2010
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.010 Biomarker group BEFREE In this study, we aimed to further elucidate the role of ESAM in tumor metastasis through angiogenic processes. 20153339 2010