LATS1, large tumor suppressor kinase 1, 9113

N. diseases: 99; N. variants: 3
Disease: Malignant Peripheral Nerve Sheath Tumor ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0751690
Disease: Malignant Peripheral Nerve Sheath Tumor
Malignant Peripheral Nerve Sheath Tumor 		0.020 Biomarker disease BEFREE Conversely, disruption of TAZ/YAP activity alleviates tumor burden in Lats1/2-deficient mice and inhibits human MPNST cell proliferation. 29438698 2018
CUI: C0751690
Disease: Malignant Peripheral Nerve Sheath Tumor
Malignant Peripheral Nerve Sheath Tumor 		0.020 Biomarker disease BEFREE Current therapies for malignant peripheral nerve sheath tumors (MPNSTs) are ineffective.The study by Wu et al. in this issue of Cancer Cell provides evidence that the HIPPO pathway is overactive in human MPNSTs and that combined modulation of LATS1/2-YAP/TAZ and PDGFR signaling in Schwann cells reduces MPNST growth. 29438691 2018