LATS1, large tumor suppressor kinase 1, 9113

N. diseases: 99; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4721806
Disease: Carcinoma, Basal Cell
Carcinoma, Basal Cell 		0.320 Biomarker disease CTD_human Functional analysis of the mutations in MYCN, PTPN14 and LATS1 suggested their potential relevance in BCC tumorigenesis. 26950094 2016
CUI: C4721806
Disease: Carcinoma, Basal Cell
Carcinoma, Basal Cell 		0.320 Biomarker disease BEFREE Functional analysis of the mutations in MYCN, PTPN14 and LATS1 suggested their potential relevance in BCC tumorigenesis. 26950094 2016
CUI: C4721806
Disease: Carcinoma, Basal Cell
Carcinoma, Basal Cell 		0.320 Biomarker disease BEFREE The present results imply that the biallelic disruption of LATS1 is a progressive factor of the infiltrative BCCs observed in this NBCCS patient and suggest that the Hippo pathway is a potential therapeutic target in cases of infiltrative BCC. 25119020 2015
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.310 AlteredExpression disease BEFREE The methylation and mRNA expression of LATS1 and LATS2 may provide useful clues to the development of the diagnostic assays for astrocytoma. 17049657 2006
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.310 Biomarker disease CTD_human The methylation and mRNA expression of LATS1 and LATS2 may provide useful clues to the development of the diagnostic assays for astrocytoma. 17049657 2006
CUI: C1368275
Disease: Pigmented Basal Cell Carcinoma
Pigmented Basal Cell Carcinoma 		0.300 Biomarker disease CTD_human Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma. 26950094 2016
CUI: C0027660
Disease: Neoplasms, Glandular and Epithelial
Neoplasms, Glandular and Epithelial 		0.300 Biomarker group CTD_human A transgenic Drosophila model for arsenic methylation suggests a metabolic rationale for differential dose-dependent toxicity endpoints. 21447609 2011
CUI: C0205854
Disease: Glandular Neoplasms
Glandular Neoplasms 		0.300 Biomarker disease CTD_human A transgenic Drosophila model for arsenic methylation suggests a metabolic rationale for differential dose-dependent toxicity endpoints. 21447609 2011
CUI: C1368683
Disease: Epithelioma
Epithelioma 		0.300 Biomarker disease CTD_human A transgenic Drosophila model for arsenic methylation suggests a metabolic rationale for differential dose-dependent toxicity endpoints. 21447609 2011
CUI: C0205768
Disease: Subependymal Giant Cell Astrocytoma
Subependymal Giant Cell Astrocytoma 		0.300 Biomarker disease CTD_human Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. 17049657 2006
CUI: C0280783
Disease: Juvenile Pilocytic Astrocytoma
Juvenile Pilocytic Astrocytoma 		0.300 Biomarker disease CTD_human Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. 17049657 2006
CUI: C0280785
Disease: Diffuse Astrocytoma
Diffuse Astrocytoma 		0.300 Biomarker disease CTD_human Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. 17049657 2006
CUI: C0334579
Disease: Anaplastic astrocytoma
Anaplastic astrocytoma 		0.300 Biomarker disease CTD_human Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. 17049657 2006
CUI: C0334580
Disease: Protoplasmic astrocytoma
Protoplasmic astrocytoma 		0.300 Biomarker disease CTD_human Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. 17049657 2006
CUI: C0334581
Disease: Gemistocytic astrocytoma
Gemistocytic astrocytoma 		0.300 Biomarker disease CTD_human Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. 17049657 2006
CUI: C0334582
Disease: Fibrillary Astrocytoma
Fibrillary Astrocytoma 		0.300 Biomarker disease CTD_human Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. 17049657 2006
CUI: C0334583
Disease: Pilocytic Astrocytoma
Pilocytic Astrocytoma 		0.300 Biomarker disease CTD_human Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. 17049657 2006
CUI: C0338070
Disease: Childhood Cerebral Astrocytoma
Childhood Cerebral Astrocytoma 		0.300 Biomarker disease CTD_human Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. 17049657 2006
CUI: C0547065
Disease: Mixed oligoastrocytoma
Mixed oligoastrocytoma 		0.300 Biomarker disease CTD_human Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. 17049657 2006
CUI: C0750935
Disease: Cerebral Astrocytoma
Cerebral Astrocytoma 		0.300 Biomarker disease CTD_human Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. 17049657 2006
CUI: C0750936
Disease: Intracranial Astrocytoma
Intracranial Astrocytoma 		0.300 Biomarker disease CTD_human Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. 17049657 2006
CUI: C1704230
Disease: Grade I Astrocytoma
Grade I Astrocytoma 		0.300 Biomarker disease CTD_human Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. 17049657 2006
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.300 GeneticVariation disease UNIPROT
CUI: C0345958
Disease: Large cell carcinoma of lung
Large cell carcinoma of lung 		0.300 GeneticVariation disease UNIPROT
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer. 30800215 2019