SLC16A4, solute carrier family 16 member 4, 9122

N. diseases: 114; N. variants: 1
Disease: Childhood Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.040 Biomarker disease BEFREE Through bioinformatics analysis, the high expression of HIF-1α, MCT1 or MCT4 indicate a poor prognosis in glioblastoma. 29928884 2018
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.040 Biomarker disease BEFREE We have previously shown that glioblastoma stem cells (GSCs) are enriched in the hypoxic tumor microenvironment, and that monocarboxylate transporter-4 (MCT4) is critical for mediating GSC signaling in hypoxia. 28655889 2017
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.040 Biomarker disease BEFREE To further explore and validate the blockade of lactic acid export as an anticancer strategy, we disrupted, via zinc finger nucleases, MCT4 and BASIGIN genes in colon adenocarcinoma (LS174T) and glioblastoma (U87) human cell lines. 25403912 2015
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.040 Biomarker disease BEFREE Inhibition of monocarboxylate transporter-4 depletes stem-like glioblastoma cells and inhibits HIF transcriptional response in a lactate-independent manner. 24077291 2014