P2RX6, purinergic receptor P2X 6, 9127

N. diseases: 85; N. variants: 4
Disease: Osteopenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029453
Disease: Osteopenia
Osteopenia 		0.020 Biomarker disease BEFREE The purinergic receptor P2X5 contributes to bone loss in experimental periodontitis. 30103845 2018
CUI: C0029453
Disease: Osteopenia
Osteopenia 		0.020 AlteredExpression disease BEFREE We therefore identified a factor, the purinergic receptor P2X5 that is highly expressed during the OC maturation phase, and which we show here plays no apparent role in early bone development and homeostasis, but which is required for osteoclast-mediated inflammatory bone loss and hyper-multinucleation of OCs. 28298636 2017