P2RX6, purinergic receptor P2X 6, 9127

N. diseases: 85; N. variants: 4
Disease: Chronic pain ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0150055
Disease: Chronic pain
Chronic pain 		0.020 Biomarker phenotype BEFREE In mice and humans, the release of eATP during inflammation or injury stimulates both innate immune activation and chronic pain through the purinergic receptor P2RX7<sup>2-4</sup>. 29973721 2018
CUI: C0150055
Disease: Chronic pain
Chronic pain 		0.020 Biomarker phenotype BEFREE ATP, known primarily as a neurotransmitter, also acts on purinoceptors (P2 purinergic receptor [P2R]) to generate the cellular calcium signaling and secretion that mediate P2R physiological manifestations, including pain.Chronic pain reduces quality of life. 29199560 2017