|
Cytomegalovirus Infections
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Viperin is expressed in atherosclerosis and induced in vascular cells by inflammatory stimuli and cytomegalovirus infection.
|
15890971 |
2005 |
|
Cytomegalovirus Infections
|
0.020 |
Biomarker
|
group |
LHGDN |
Viperin is expressed in atherosclerosis and induced in vascular cells by inflammatory stimuli and cytomegalovirus infection.
|
15890971 |
2005 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The putative functions of viperin in atherosclerosis may relate to disease-associated microbes.
|
15890971 |
2005 |
|
Atherosclerosis
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
The putative functions of viperin in atherosclerosis may relate to disease-associated microbes.
|
15890971 |
2005 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The putative functions of viperin in atherosclerosis may relate to disease-associated microbes.
|
15890971 |
2005 |
|
Hepatitis C
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Transient expression of viperin in cells harboring the HCV genomic replicon resulted in a significant decrease in HCV replication, suggesting that viperin has anti-HCV activity.
|
16108059 |
2005 |
|
Hepatitis C, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector.
|
16108059 |
2005 |
|
Myocardial Ischemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study.
|
16214533 |
2005 |
|
Rhinovirus infection
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Viperin expression was further examined and also was increased in naturally acquired rhinovirus infections, as well as in cultured human epithelial cells infected with intact, but not replication-deficient, rhinovirus.
|
18658112 |
2008 |
|
Japanese Encephalitis
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
In this study, we found that viperin is highly induced at the RNA level by Japanese encephalitis virus (JEV) and Sindbis virus (SIN) and that viperin protein is degraded in JEV-infected cells through a proteasome-dependent mechanism.
|
18768981 |
2008 |
|
Rhinovirus infection
|
0.020 |
Biomarker
|
disease |
BEFREE |
The mRNA expression of the antiviral genes, type I interferon-β and type III interferon-λ1, interferon-λ2/3, and interferon-stimulated genes (retinoic acid inducible gene I, melanoma differentiation associated gene 5, oligoadenylate synthase, MxA and viperin) and pro-inflammatory cytokines (interleukin (IL)-6 and IL-8), and rhinovirus replication and release were measured.
|
20150207 |
2010 |
|
Hepatitis C
|
0.040 |
Biomarker
|
disease |
BEFREE |
In summary, these findings suggest a novel mechanism by which viperin inhibits HCV replication, possibly through binding to host protein hVAP-33 and interfering with its interaction with NS5A.
|
21957124 |
2012 |
|
Hepatitis C
|
0.040 |
Biomarker
|
disease |
BEFREE |
In conclusion, we propose that viperin interacts with NS5A and the host factor, VAP-A, to limit HCV replication at the replication complex.
|
22045669 |
2011 |
|
Influenza
|
0.330 |
Biomarker
|
disease |
BEFREE |
Young and old viperin-knockout (KO) mice and WT control animals were challenged with influenza WSN33 at lethal doses of 10(3) and 10(4) p.f.u. via the intratracheal route.
|
22377585 |
2012 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo and in vitro studies on the antiviral activities of viperin against influenza H1N1 virus infection.
|
22377585 |
2012 |
|
HIV-1 infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus viperin may contribute to persistent noncytopathic HIV-1 infection of macrophages and possibly to biologic differences with HIV-1-infected T cells.
|
22677126 |
2012 |
|
Influenza
|
0.330 |
Biomarker
|
disease |
BEFREE |
Viperin, also known as RSAD2, is an interferon-inducible protein that potently restricts a broad range of different viruses such as influenza, hepatitis C virus, human cytomegalovirus and West Nile virus.
|
22734835 |
2012 |
|
West Nile viral infection
|
0.020 |
Biomarker
|
disease |
BEFREE |
Viperin, also known as RSAD2, is an interferon-inducible protein that potently restricts a broad range of different viruses such as influenza, hepatitis C virus, human cytomegalovirus and West Nile virus.
|
22734835 |
2012 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.010 |
Biomarker
|
disease |
BEFREE |
Since HIV-1 and other retroviruses depend on lipid domains of the host cell for budding and infectivity, we investigated the possibility that Viperin also restricts human immunodeficiency virus and other retroviruses.
|
22734835 |
2012 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, these data indicated that viperin plays a significant role in the innate immune defense against RSV.
|
23018837 |
2013 |
|
Chikungunya Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data demonstrate that viperin is a critical antiviral host protein that controls CHIKV infection and provide a preclinical basis for the design of effective control strategies against CHIKV and other reemerging arthrogenic alphaviruses.
|
23160199 |
2012 |
|
Influenza
|
0.330 |
Biomarker
|
disease |
CTD_human |
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
|
23326326 |
2013 |
|
Venous Thromboembolism
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
|
23509962 |
2013 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The host protein viperin is an interferon stimulated gene (ISG) that is up-regulated during a number of viral infections.
|
23638199 |
2013 |
|
Dengue Fever
|
0.030 |
Biomarker
|
disease |
BEFREE |
In this study we have shown that dengue virus type-2 (DENV-2) infection significantly induced viperin, co-incident with production of viral RNA and via a mechanism requiring retinoic acid-inducible gene I (RIG-I).
|
23638199 |
2013 |