|
Influenza
|
0.330 |
Biomarker
|
disease |
BEFREE |
Additionally, significant DEGs in module 2, including radical S‑adenosyl methionine domain containing 2 (RSAD2), 2'‑5'‑oligoadenylate synthetase 2 (OAS2), myxovirus (influenza virus) resistance 1 (MX1) and ISG15 ubiquitin‑like modifier (ISG15), were predominantly associated with immune function pathways.
|
27356888 |
2016 |
|
Influenza
|
0.330 |
Biomarker
|
disease |
CTD_human |
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
|
23326326 |
2013 |
|
Influenza
|
0.330 |
Biomarker
|
disease |
BEFREE |
Young and old viperin-knockout (KO) mice and WT control animals were challenged with influenza WSN33 at lethal doses of 10(3) and 10(4) p.f.u. via the intratracheal route.
|
22377585 |
2012 |
|
Influenza
|
0.330 |
Biomarker
|
disease |
BEFREE |
Viperin, also known as RSAD2, is an interferon-inducible protein that potently restricts a broad range of different viruses such as influenza, hepatitis C virus, human cytomegalovirus and West Nile virus.
|
22734835 |
2012 |
|
Myocardial Ischemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study.
|
16214533 |
2005 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Chicken viperin inhibits Newcastle disease virus infection in vitro: A possible interaction with the viral matrix protein.
|
31003187 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The viperin protein is highly induced after viral infection and exhibit broad-spectrum antiviral activity.
|
29046456 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The interferon stimulated gene (ISG) viperin has drawn our attention as it has been highlighted as an important antiviral protein against several viral infections.
|
29202415 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Viperin is an interferon (IFN)-stimulated gene product, which is part of the first line of the intracellular response against viral infection.
|
30059238 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Nasal viperin index was found to be a robust marker of viral respiratory tract infection with a sensitivity of 80% and specificity of 94% in distinguishing children with symptomatic virus infections from asymptomatic virus-negative children.
|
28968760 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Viperin is an interferon-inducible antiviral protein, responsible for antiviral response to a variety of viral infections.
|
29254175 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, we provide the first evidences that amphioxus viperin, like that of vertebrates, is capable of promoting resistance against viral infection in vitro and in vivo, indicating that viperin-mediated antiviral response already emerged in the primitive chordate.
|
26190498 |
2015 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Viperin in concert with a number of other ISGs was upregulated in response to viral nucleic acid mimics and sendai virus in the C. porosus cell line, LV-1, indicating an intact early innate response to viral infection in these animals for the first time.
|
25766282 |
2015 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The host protein viperin is an interferon stimulated gene (ISG) that is up-regulated during a number of viral infections.
|
23638199 |
2013 |
|
Venous Thromboembolism
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
|
23509962 |
2013 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo and in vitro studies on the antiviral activities of viperin against influenza H1N1 virus infection.
|
22377585 |
2012 |
|
Zika Virus Infection
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We confirmed that transient overexpression of rVP<sup>wt</sup> prior to ZIKV infection dramatically reduced viral replication in A549 cells.
|
30934824 |
2019 |
|
Hepatitis C
|
0.040 |
Biomarker
|
disease |
BEFREE |
Viperin, a member of the radical S-adenosyl-L-methionine (SAM) superfamily of enzymes, is an interferon-inducible protein implicated in the inhibition of replication of a broad range of RNA and DNA viruses, including dengue virus, West Nile virus, hepatitis C virus, influenza A virus, rabies virus <sup>2</sup> and HIV<sup>3,4</sup>.
|
29925952 |
2018 |
|
Zika Virus Infection
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Transduction of microglial CHME3 cells with a viperin lentiviral expression vector rendered them resistant to ZIKV infection, preventing the synthesis of viral RNA and protein.
|
30036788 |
2018 |
|
Zika Virus Infection
|
0.040 |
Biomarker
|
disease |
BEFREE |
Here we describe a novel antiviral mechanism employed by viperin against two prominent flaviviruses, tick-borne encephalitis virus (TBEV) and Zika virus (ZIKV).
|
29321318 |
2018 |
|
Zika Virus Infection
|
0.040 |
Biomarker
|
disease |
BEFREE |
Viperin is an important host restriction factor in control of Zika virus infection.
|
28667332 |
2017 |
|
Hepatitis C
|
0.040 |
Biomarker
|
disease |
BEFREE |
In summary, these findings suggest a novel mechanism by which viperin inhibits HCV replication, possibly through binding to host protein hVAP-33 and interfering with its interaction with NS5A.
|
21957124 |
2012 |
|
Hepatitis C
|
0.040 |
Biomarker
|
disease |
BEFREE |
In conclusion, we propose that viperin interacts with NS5A and the host factor, VAP-A, to limit HCV replication at the replication complex.
|
22045669 |
2011 |
|
Hepatitis C
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Transient expression of viperin in cells harboring the HCV genomic replicon resulted in a significant decrease in HCV replication, suggesting that viperin has anti-HCV activity.
|
16108059 |
2005 |
|
Dengue Fever
|
0.030 |
Biomarker
|
disease |
BEFREE |
In all models, viperin was increased following DENV infection.
|
31774391 |
2020 |