EXO1, exonuclease 1, 9156

N. diseases: 74; N. variants: 17
Disease: Hyperactive behavior ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior 		0.020 Biomarker phenotype BEFREE In summary, PARG-2 deficiency in C. elegans causes hyperactive DSB end resection likely through EXO-1 overproduction. 31593615 2020
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior 		0.020 Biomarker phenotype BEFREE These results suggest that 'rewiring' of BRCA1-deficient cells to employ an Exo1-independent hyper-resection pathway is a driver of PARPi resistance. 29697047 2018