|
Breast Carcinoma
|
0.430 |
AlteredExpression
|
disease |
BEFREE |
High expression level of EXO1 protein was significantly associated with poor OS in breast cancer patients (p=0.03).
|
31777591 |
2019 |
|
Breast Carcinoma
|
0.430 |
Biomarker
|
disease |
BEFREE |
We tested seven polymorphisms in DNA repair genes XRCC1, ERCC2, XRCC3, XRCC2, EXOI and TP53 for a possible association with breast cancer risk in a sample of 672 case and 672 control Russian women.
|
25537147 |
2016 |
|
Breast Carcinoma
|
0.430 |
GeneticVariation
|
disease |
BEFREE |
Our results provide evidence that the A allele of EXO1 K589E may be associated with the development of breast cancer and may be a useful biomarker for breast cancer detection and primary prevention.
|
19846925 |
2009 |
|
Colorectal Carcinoma
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
In addition, polymorphisms of EXO1, LIG3, and PolB may modulate the risk of colorectal cancer by decreasing (PolB) or increasing (LIG3 and EXO1) the chance of malignant transformation.
|
26649135 |
2016 |
|
Colorectal Carcinoma
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to examine the association between the L757P polymorphism at exon 13 of the EXO1 gene and the risk of CRC in Iranian patients.
|
20854105 |
2010 |
|
Colorectal Carcinoma
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
The EXO1 genotypes were not associated with any clinicopathological characteristics in colorectal cancer patients.
|
15550454 |
2005 |
|
Colorectal Carcinoma
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
Hereditary non-polyposis colorectal cancer and the role of hPMS2 and hEXO1 mutations.
|
14756672 |
2004 |
|
Colorectal Carcinoma
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
In one recent study, germline variants of EXO1 were reported to be associated with predisposition to colorectal cancer in families with phenotypes similar to hereditary nonpolyposis colon cancer (HNPCC).
|
14623461 |
2003 |
|
Colorectal Carcinoma
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
We evaluated a series of European CRC patients and population controls to clarify whether EXO1 variants may indeed predispose to familial CRC.
|
12517792 |
2003 |
|
Hereditary Nonpolyposis Colorectal Cancer
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
We have, in addition discovered a polygenic interaction which is the most likely cause of cancer development in a HNPCC patient that could explain previous inconsistent results reported on an intronic EXO1 variant.
|
26811195 |
2016 |
|
Hereditary Nonpolyposis Colorectal Cancer
|
0.350 |
Biomarker
|
disease |
BEFREE |
This study questions the functional significance of previously reported variants of EXO1 reported in HNPCC-like families and suggests that in humans there may be other as yet undiscovered proteins that have exonuclease function overlapping with that of EXO1 in DNA mismatch repair.
|
14623461 |
2003 |
|
Hereditary Nonpolyposis Colorectal Cancer
|
0.350 |
Biomarker
|
disease |
BEFREE |
Thus, little evidence was obtained to support a major causative role of EXO1 in HNPCC, although we cannot exclude a role for EXO1 as a low penetrance cancer susceptibility or modifying gene.
|
12517792 |
2003 |
|
Hereditary Nonpolyposis Colorectal Cancer
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
Recently, eight missense mutations in hEXO1 were identified in atypical HNPCC patients, who have been screened to be negative for hMSH2, hMLH1, and hMSH6 mutations.
|
12414623 |
2002 |
|
Hereditary Nonpolyposis Colorectal Cancer
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
Germline variants of EXO1 were detected in 14 patients, including one splice-site mutation in a family with HNPCC and 13 missense mutations in patients with atypical HNPCC.
|
11375940 |
2001 |
|
Liver carcinoma
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
A significant copy number variation (CNV) of the Exo1 gene was found in HCC specimens in three separate sets of published microarray data.
|
30328366 |
2018 |
|
Liver carcinoma
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Associations between single-nucleotide polymorphisms of human exonuclease 1 and the risk of hepatocellular carcinoma.
|
27894089 |
2016 |
|
Liver carcinoma
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Because our results suggest for the first time that the Lys/Lys homozygote genotype of Exo 1 K589E polymorphism may be a genetic susceptibility factor for HCC in the Turkish population, further independent studies are required to validate our findings in a larger series, as well as in patients of different ethnic origins.
|
22205538 |
2012 |
|
Liver carcinoma
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
No statistically significant differences were found in the allele or genotype distributions of the Exo 1 T439M polymorphism among HCC and cancer-free control subjects (P>0.05).
|
22296401 |
2011 |
|
Malignant neoplasm of breast
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
High expression level of EXO1 protein was significantly associated with poor OS in breast cancer patients (p=0.03).
|
31777591 |
2019 |
|
Malignant neoplasm of breast
|
0.330 |
Biomarker
|
disease |
BEFREE |
We tested seven polymorphisms in DNA repair genes XRCC1, ERCC2, XRCC3, XRCC2, EXOI and TP53 for a possible association with breast cancer risk in a sample of 672 case and 672 control Russian women.
|
25537147 |
2016 |
|
Malignant neoplasm of breast
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Our results provide evidence that the A allele of EXO1 K589E may be associated with the development of breast cancer and may be a useful biomarker for breast cancer detection and primary prevention.
|
19846925 |
2009 |
|
Colorectal Neoplasms
|
0.330 |
GeneticVariation
|
group |
BEFREE |
Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability.
|
14623461 |
2003 |
|
Mammary Neoplasms
|
0.320 |
AlteredExpression
|
group |
BEFREE |
Analysis of mRNA expression profiles in breast tumors demonstrates that those with lower Trex1 and higher BLM and EXO1 expression levels are associated with poor prognosis.
|
28279982 |
2017 |
|
Mammary Neoplasms
|
0.320 |
Biomarker
|
group |
BEFREE |
Expression of EXO1 module was found as indicative of elevated cell proliferation, genomic instability, activated RAS/AKT/MYC/E2F1 signaling pathways and loss of p53 activity in breast tumors. mRNA-drug connectivity analysis indicates inhibition of RAS/PI3K as a possible targeted therapeutic approach for the patients with activated EXO1 module in breast tumors.
|
24147022 |
2013 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Validation in The Cancer Genome Atlas primary cohort indicated EXO1 expression was significantly associated with lymph node Met and disease-free survival.
|
30775798 |
2019 |