|
Acute Lung Injury
|
0.300 |
Therapeutic
|
disease |
CTD_human |
Adenovirus-mediated overexpression of soluble ST2 provides a protective effect on lipopolysaccharide-induced acute lung injury in mice.
|
21352201 |
2011 |
|
Acute lymphocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We cloned the der (11) and der (4) breakpoints and isolated the fusion transcripts in the cell line MV4-11 and in a de novo acute lymphoblastic leukemia (ALL).
|
10671636 |
1999 |
|
Acute Undifferentiated Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we use Cbfb-MYH11 knock-in mice to show that IL1RL1 is expressed by cell populations with high LSC activity, and that the cell surface expression of IL1RL1 is dynamic, implying that the expression of IL1RL1 is not restricted to a specific stage of differentiation.
|
30742053 |
2019 |
|
Adenocarcinoma of pancreas
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
As IL-33 mediates its effects via the heterodimeric ST2L/IL-1 receptor accessory protein (IL-1RAcP) receptor complex, we investigated the influence of IL-33 alone, IL-33 combined with IL-1 and other inflammatory cytokines on IL-33 receptor/ligand mRNA expression and production of tumorigenic factors in the highly metastatic human pancreatic adenocarcinoma cell line Colo357.
|
22819319 |
2012 |
|
Adult Acute Lymphocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We cloned the der (11) and der (4) breakpoints and isolated the fusion transcripts in the cell line MV4-11 and in a de novo acute lymphoblastic leukemia (ALL).
|
10671636 |
1999 |
|
Adult Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A t(11;14)(q13;q32) was consistently observed in one patient with cb-cc lymphoma together with inv(1) (p22p36), der(4)t(4;?)(p16;?), del(6)(q13) and other variable changes.
|
1913607 |
1991 |
|
Adult onset asthma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
|
31036433 |
2019 |
|
Allergic asthma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate whether the genetic polymorphisms of CDHR3 (rs6967330), GSDMB (rs2305480), IL33 rs928413, RAD50 (rs6871536) and IL1RL1 (rs1558641) are associated with the development of atopic asthma in Chinese population.
|
26493291 |
2015 |
|
Allergic Reaction
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
|
29083406 |
2017 |
|
Allergic Reaction
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
|
Allergic Reaction
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
|
23817569 |
2013 |
|
Allergic Reaction
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.
|
29785011 |
2018 |
|
Allergic rhinitis (disorder)
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
|
30013184 |
2018 |
|
Allergic sensitization
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
|
23817571 |
2013 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
We uncovered several promising tissue-specific regulatory TFs or genes for Alzheimer's disease (e.g.ZIC1 and STX1B) and asthma (e.g.CSF3 and IL1RL1).
|
29378629 |
2018 |
|
Alzheimer's Disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the increased expression of ST-II and -III coincided with the elevated levels of c-series gangliosides (A2B5+ antigens) in AD NSCs.
|
26699276 |
2016 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recent studies indicate a protective role for IL-33 and ST2L in atherosclerosis, obesity and cardiac remodeling.
|
21356240 |
2011 |
|
Arthritis, Adjuvant-Induced
|
0.300 |
Biomarker
|
disease |
CTD_human |
IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy.
|
20472598 |
2010 |
|
Arthritis, Collagen-Induced
|
0.300 |
Biomarker
|
disease |
CTD_human |
IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy.
|
20472598 |
2010 |
|
Arthritis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy.
|
20472598 |
2010 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of a new locus at 16q12 associated with time to asthma onset.
|
27130862 |
2016 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls).
|
19198610 |
2009 |
|
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
ST2L expression was increased in severe asthma (P = .02) and associated with multiple indicators of TH2-like inflammation, including blood eosinophils (P = .001), exhaled nitric oxide (P = .003), and epithelial CLCA1 (P < .0001) and eotaxin-3 (P = .001) mRNA expression.
|
25091434 |
2015 |
|
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We assessed in the prospective birth cohort Prevention and Incidence of Asthma and Mite Allergy (PIAMA) whether IL1RL1 SNPs associate with levels of its soluble transcript IL1RL1 (IL1RL1-a) in serum, blood eosinophil counts, and asthma prevalence from birth to age 8 years, and whether IL1RL1-a serum levels associate with blood eosinophil counts.
|
21281963 |
2011 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, the IL1RL1, HLA, IL13 and C11orf30 regions are overlapping susceptibility loci among atopic dermatitis and asthma or allergic rhinitis.
|
23439055 |
2013 |