Accordingly, molecules involved in necroptotic signaling, such as receptor-interacting serine/threonine-protein kinase 3 (<i>RIPK3</i>) and mixed lineage kinase-like (<i>MLKL</i>) have been found to stimulate anticancer immune responses in mouse models of chemotherapy. mRNAs encoding prominent pro-necrotic gene products (<i>RIPK1</i>, <i>RIPK3</i>, <i>MLKL</i>, <i>PGAM5</i> and <i>DFNA5</i>) were correlated with immune-related metagenes in several cancer types (breast, colorectal, lung, ovary, melanoma), revealing the strongest associations in breast cancer.
Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.