DCLK1, doublecortin like kinase 1, 9201

N. diseases: 123; N. variants: 17
Disease: Liver carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.060 Biomarker disease BEFREE Further study revealed that DCLK1/PI3K/matrix metalloproteinase (MMP) 2 (MMP-2) was an important pathway that mediated the effect of SETD3 on HCC metastasis. 31654063 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.060 AlteredExpression disease BEFREE Multivariate analysis also demonstrated that DCLK1 expression was an independent prognostic factor for DFS in HCC (P=0.019; hazard ratio, 1.546; 95% confidence interval, 1.330-1.725). 29344199 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.060 Biomarker disease BEFREE Rescue experiments demonstrated that co-transfection of DCLK1 lacking the 3'-untranslated region partially prevented miR-613-induced suppression of HCC cell proliferation and invasion. 27049311 2016
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.060 AlteredExpression disease BEFREE Analysis of the Cancer Genome Atlas' HCC dataset revealed that DCLK1 is overexpressed in HCC tumors relative to adjacent normal tissues. 26468984 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.060 AlteredExpression disease BEFREE The DCLK1 overexpression also correlates with increased levels of S100A9, c-Myc, and BRM levels in HCV/HBV-positive patients with cirrhosis and HCC. 25948779 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.060 Biomarker disease BEFREE The DCAMKL-1-positive cells isolated from hepatoma cell lines by fluorescence-activated cell sorting (FACS) form spheroids in Matrigel. 21937640 2011