Premature Menopause
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of BMP15 and GDF9 variants to premature ovarian insufficiency.
|
31392662 |
2019 |
Premature Menopause
|
0.200 |
Biomarker
|
disease |
BEFREE |
The role of BMP15 and GDF9 in the pathogenesis of primary ovarian insufficiency.
|
31607184 |
2019 |
Premature Menopause
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The significant consequences of mutations in the GDF9 and BMP15 genes in women with dizygotic twins as well as the clinical relevance of these oocyte factors in the pathogenesis of primary ovarian insufficiency and polycystic ovary syndrome are also addressed.
|
29544636 |
2018 |
Premature Menopause
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A novel homozygous mutation of bone morphogenetic protein 15 identified in a consanguineous marriage family with primary ovarian insufficiency.
|
29169851 |
2018 |
Premature Menopause
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
BMP15 Mutations Associated With Primary Ovarian Insufficiency Reduce Expression, Activity, or Synergy With GDF9.
|
28359091 |
2017 |
Premature Menopause
|
0.200 |
Biomarker
|
disease |
BEFREE |
BMP15 "knockout-like" effect in familial premature ovarian insufficiency with persistent ovarian reserve.
|
28094433 |
2017 |
Premature Menopause
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A total of three SNPs were detected within the BMP15 gene, including rs3810682 (-9C>G), rs79377927 (788_789insTCT) and rs17003221 (852C>T), and no significant differences were observed in the frequencies of the -9C>G and 852C>T genotypes between the POF and control groups (7.94, vs. 6.90% and 4.76, vs. 3.45%, respectively).
|
25954833 |
2015 |
Premature Menopause
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A novel FOXL2 gene mutation and BMP15 variants in a woman with primary ovarian insufficiency and blepharophimosis-ptosis-epicanthus inversus syndrome.
|
25988799 |
2015 |
Premature Menopause
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A functional association between the BMP15 c.-9C>G promoter polymorphism and cause of POF have been reported.
|
25246117 |
2014 |
Premature Menopause
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Positive selection in bone morphogenetic protein 15 targets a natural mutation associated with primary ovarian insufficiency in human.
|
24147118 |
2013 |
Premature Menopause
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have discovered several mutations in the screening of BMP15 in premature ovarian failure but none in PCOS.
|
22014425 |
2011 |
Premature Menopause
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Similarly, large numbers of mutations in the GDF9 and BMP15 genes have been identified in women with premature ovarian failure and in mothers of dizygotic twins.
|
21226076 |
2011 |
Premature Menopause
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Nine variants of the BMP15 gene including six missense substitutions and one insertion of three nucleotides were identified in the POF group.
|
20364024 |
2010 |
Premature Menopause
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
BMP15 mutations associated with primary ovarian insufficiency cause a defective production of bioactive protein.
|
19263482 |
2009 |
Premature Menopause
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Caution is recommended in the interpretation of BMP15 mutations in the context of POF.
|
17826728 |
2008 |
Premature Menopause
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our findings indicate that mutations in BMP-15 exons, or changes in BMP-15 pro-peptide, are rare in Chinese women with POF.
|
17464588 |
2007 |
Premature Menopause
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, three single nucleotide polymorphisms in the BMP15 gene, two in the 5' untranslated region (31T>G and 71C>G) and another in exon 1 (387G>A), were found to be common in both POF and control groups.
|
17027369 |
2006 |
Premature Menopause
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In the human, a heterozygous point mutation of BMP15 has been associated with premature ovarian failure (POF).
|
16645022 |
2006 |
Premature Menopause
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Sequence analysis of the coding region of the BMP15 gene was carried out in a cohort of women with POF (n=133), primary amenorrhoea (n=60), and secondary amenorrhoea (n=9) compared with control females (n=197).
|
16508750 |
2006 |
Premature Menopause
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The objective of the study was to verify the involvement of BMP15 variations in a large POF population.
|
16464940 |
2006 |
Premature Menopause
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The missense mutation in the GDF-9 gene or the GDF-9B/BMP-15 gene is uncommon in anovulatory Japanese women with POF and PCOS.
|
11056243 |
2000 |
Premature Menopause
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|