DAPL1, death associated protein like 1, 92196

N. diseases: 2; N. variants: 2
Disease: Age related macular degeneration ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.020 AlteredExpression disease BEFREE Here we show that Dapl1, whose human homolog represents a susceptibility locus for age-related macular degeneration (AMD), is highly up-regulated in quiescent but not proliferating RPE cells and that experimental overexpression of DAPL1 in proliferating RPE cells inhibits their proliferation. 28334846 2017
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.020 Biomarker disease BEFREE DAPL1 plays a role in epithelial differentiation and may be involved in apoptotic processes thereby suggesting a possible novel pathway in AMD pathogenesis. 25680934 2015