|
Liver carcinoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
Our data demonstrate that PTTG1 is involved in TNF-α-related HCC via c-myc induction and that PTTG1 may be a potential therapeutic target for HCC.
|
31385458 |
2019 |
|
Liver carcinoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma.
|
29803224 |
2018 |
|
Liver carcinoma
|
0.370 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
|
Liver carcinoma
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
A Aconitum coreanum polysaccharide fraction induces apoptosis of hepatocellular carcinoma (HCC) cells via pituitary tumor transforming gene 1 (PTTG1)-mediated suppression of the P13K/Akt and activation of p38 MAPK signaling pathway and displays antitumor activity in vivo.
|
25874498 |
2015 |
|
Liver carcinoma
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the PTTG1 gene is up-regulated in the cancerous tissue from patients with HCC and involved in the progression of HCC.
|
21099350 |
2011 |
|
Liver carcinoma
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
The PTTG1 mRNA and protein expression were repressed by T(3) in HCC cell lines overexpressing TR.
|
18339849 |
2008 |
|
Liver carcinoma
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
However, the expression and pathogenic implications of the PTTG gene family in hepatocellular carcinoma are largely unknown.
|
16628636 |
2006 |
|
Liver carcinoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
In conclusion, PTTG1 might be critically involved in the development of HCCs through the promotion of angiogenesis.
|
16628605 |
2006 |
|
Psoriasis
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
The association of variants in the ADRA1B gene with psoriasis could explain why variants in the IL-12B, ADRA1B and PTTG1 gene regions are associated with psoriasis.
|
30785334 |
2019 |
|
Psoriasis
|
0.320 |
Biomarker
|
disease |
BEFREE |
The present study was conducted to clarify the less well-known roles of PTTG1 in the pathophysiology of psoriasis, focusing on its relationship with tumor necrosis factor-α (TNF-α), which is a critical mediator of the disease.
|
23677169 |
2013 |
|
Psoriasis
|
0.320 |
Biomarker
|
disease |
CTD_human |
We identified six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A (combined P < 5 × 10⁻⁸) and replicated one locus, 5q33.1 (TNIP1-ANXA6), previously reported (combined P = 3.8 × 10⁻²¹) in the European studies.
|
20953187 |
2010 |
|
Pituitary Neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
A preliminary experiment showed a positive correlation between ECT2 and pituitary tumor-transforming gene 1 (PTTG1).
|
30590814 |
2019 |
|
Pituitary Neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
The pituitary tumor-transforming gene 1 (PTTG1), also known as Securin, is considered an oncogene.
|
30871916 |
2019 |
|
Pituitary Neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
Tumor tissues from 28 corticotroph adenomas (female 26, male 2, mean age 39.21 ± 10.39 years) were subject to immunohistochemical study using the following antibodies: pituitary tumor-transforming gene 1 (PTTG1), cyclin D1, p16, p27, brahma related-gene 1 (Brg1), and Ki-67.
|
30474823 |
2019 |
|
Pituitary Neoplasms
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Pituitary tumor-transforming gene 1 (PTTG1), an oncoprotein that regulates cell proliferation, is highly expressed in several types of cancer cells including leukemia.
|
29649138 |
2018 |
|
Pituitary Neoplasms
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Pituitary-tumor transforming gene (PTTG1) has been shown to modulate cancer invasiveness and response to therapy.
|
29218429 |
2018 |
|
Pituitary Neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
Pituitary tumor-transforming gene 1 (PTTG1) is identified as an oncogene, and overexpresses in many tumors.
|
27893422 |
2017 |
|
Pituitary Neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
Pituitary tumor-transforming gene-1 (PTTG1) could acquire its metastasis-promoting effects via inducing epithelial-mesenchymal transition (EMT).
|
29190924 |
2017 |
|
Pituitary Neoplasms
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Pituitary tumor-transforming gene-1 (PTTG1) is a transcription factor that can affect transcriptional activity, angiogenesis, and cell senescence.
|
25627474 |
2016 |
|
Pituitary Neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
Pituitary tumor transforming gene-1 (PTTG1) is a novel oncogene and overexpressed in a wide variety of human cancers.
|
27829547 |
2016 |
|
Pituitary Neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
A role of Pituitary Tumor Transforming Gene 1 (Pttg1) in the carcinogenesis has been shown in some cancers, but not in BC (BC).
|
26824458 |
2016 |
|
Pituitary Neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
In this study we investigated the expression and immunogenicity of the CTAs, Sperm Protein 17 (SP17), A-kinase anchor protein 4 (AKAP4) and Pituitary Tumor Transforming Gene 1 (PTTG1) in human non-small cell lung cancer (NSCLC) cell lines and primary tumors.
|
25739119 |
2015 |
|
Pituitary Neoplasms
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Pituitary tumor-transforming gene 1 (Pttg1) has been recently reported to promote cancer cell growth and metastasis in a number of various tumors.
|
25877755 |
2015 |
|
Pituitary Neoplasms
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Pituitary tumor-transforming gene (PTTG), the index mammalian securin, is abundantly expressed in several tumors and regulates tumor growth and progression.
|
23416975 |
2014 |
|
Pituitary Neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
Pituitary tumor-transforming gene 1 (PTTG1) is overexpressed in oral squamous cell carcinoma (OSCC) and promotes migration, invasion and epithelial-mesenchymal transition (EMT) in SCC15 cells.
|
24879625 |
2014 |