|
Malignant neoplasm of stomach
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
Stratified analysis indicated that risks of GC and its precursors were elevated in subjects with IL-32 rs2015620 A allele (AA + AT) or IL-22 rs1179251 CC genotype and H. pylori infection, and significant interactions between these two SNPs and H. pylori infection were found.
|
26358252 |
2016 |
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study shows a functional effect of a promoter single-nucleotide polymorphism (SNP) in IL32 on lipid profiles in RA patients and individuals, suggesting a possible protective role of this SNP against CVD.
|
28134327 |
2017 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The analysis revealed an interaction between IL8 -251A>T and IL32 rs28372698 SNPs among cases with moderately- or well-differentiated tumors.
|
24982364 |
2014 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our data suggest a possible survival mechanism by the splicing of IL-32γ to IL-32β and also IL-6, IL-8, and CXCR1 signaling pathways to reverse the proapoptotic effect of the IL-32γ isoform, leading to tumor cell survival and thus favoring tumor progression.
|
29037857 |
2018 |
|
Tumor Progression
|
0.070 |
GeneticVariation
|
phenotype |
BEFREE |
Our data suggest a possible survival mechanism by the splicing of IL-32γ to IL-32β and also IL-6, IL-8, and CXCR1 signaling pathways to reverse the proapoptotic effect of the IL-32γ isoform, leading to tumor cell survival and thus favoring tumor progression.
|
29037857 |
2018 |
|
Stomach Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Stratified analysis indicated that risks of GC and its precursors were elevated in subjects with IL-32 rs2015620 A allele (AA + AT) or IL-22 rs1179251 CC genotype and H. pylori infection, and significant interactions between these two SNPs and H. pylori infection were found.
|
26358252 |
2016 |
|
Malignant neoplasm of lung
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Our study indicates the importance of IL-32 polymorphism and mRNA expression in susceptibility and influence of survival status in lung cancer.
|
27775437 |
2017 |
|
Malignant neoplasm of lung
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Some IL-32 isoforms have been linked to disease outcome and were shown to positively influence tumor development and progression in various different malignancies, including gastric, breast and lung cancers.
|
29747940 |
2018 |
|
Carcinoma of lung
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Our study indicates the importance of IL-32 polymorphism and mRNA expression in susceptibility and influence of survival status in lung cancer.
|
27775437 |
2017 |
|
Primary malignant neoplasm of lung
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Our study indicates the importance of IL-32 polymorphism and mRNA expression in susceptibility and influence of survival status in lung cancer.
|
27775437 |
2017 |
|
Cardiovascular Diseases
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Interleukin-32 (IL-32) is a cytokine associated with higher risk of cardiovascular diseases in inflammatory environments.
|
31326419 |
2019 |
|
Cardiovascular Diseases
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Our study shows a functional effect of a promoter single-nucleotide polymorphism (SNP) in IL32 on lipid profiles in RA patients and individuals, suggesting a possible protective role of this SNP against CVD.
|
28134327 |
2017 |
|
HIV Infections
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Our data demonstrate that rs4349147-G promotes transcription of non-IL-32α isoforms, generating a proinflammatory environment more conducive to HIV infection.
|
29507875 |
2018 |
|
Multiple Sclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The present study was an attempt to reveal any association between IL-32 levels and C/T promoter SNP with susceptibility to MS.
|
28716229 |
2017 |
|
Infection caused by Helicobacter pylori
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Stratified analysis indicated that risks of GC and its precursors were elevated in subjects with IL-32 rs2015620 A allele (AA + AT) or IL-22 rs1179251 CC genotype and H. pylori infection, and significant interactions between these two SNPs and H. pylori infection were found.
|
26358252 |
2016 |
|
Malignant neoplasm of endometrium
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrates that IL-32 gene polymorphisms are significantly associated with increased EC susceptibility in Chinese Han women.
|
25663496 |
2015 |
|
Dental caries
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Three loci at the genes interleukin 32 (IL32), galactokinase 2 (GALK2), and CUGBP, Elav-like family member 4 (CELF4) were linked to S. mutans carriage, and there was a severity of caries at a suggestive significance level among COHRA children (P < 9 × 10<sup>-5</sup>), and at a nominal significance level among GEIRS children (P = 0.047-0.001).
|
31148553 |
2019 |
|
Polycystic Ovary Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
There were significant differences between PCOS and healthy women regarding IL-17A rs2275913 alleles, genotypes frequencies (p=0.005, and 0.01, respectively) and the allelic distribution of IL-32 rs9927163 SNP (p=0.03).
|
30848577 |
2019 |
|
Caries (morphologic abnormality)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Three loci at the genes interleukin 32 (IL32), galactokinase 2 (GALK2), and CUGBP, Elav-like family member 4 (CELF4) were linked to S. mutans carriage, and there was a severity of caries at a suggestive significance level among COHRA children (P < 9 × 10<sup>-5</sup>), and at a nominal significance level among GEIRS children (P = 0.047-0.001).
|
31148553 |
2019 |
|
Endometrial Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrates that IL-32 gene polymorphisms are significantly associated with increased EC susceptibility in Chinese Han women.
|
25663496 |
2015 |
|
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
BEFREE |
Hence, it can be concluded that IL-32θ is an anti-inflammatory cytokine that can act as a tumor suppressor and can play vital role in colon cancer therapies.
|
29218075 |
2017 |
|
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
BEFREE |
These findings provide evidence of the potential involvement of IL-32 in the development of obesity-associated CC as a pro-inflammatory and ECM remodeling cytokine.
|
28811968 |
2017 |
|
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
CTD_human |
Expression of acidosis-dependent genes in human cancer nests.
|
25279216 |
2014 |
|
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
BEFREE |
These findings indicate that IL-32α suppressed colon cancer development by promoting the death signaling of TNFR1.
|
25909160 |
2015 |
|
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
BEFREE |
IL-32γ enhances TNF-α-induced cell death in colon cancer.
|
23255489 |
2014 |